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The Notch gene in Drosophila encodes a transmembrane protein with homology to EGF that appears to mediate cell-cell interactions necessary for proper epidermal vs. neural fate decisions. In this study, we examine Notch expression in detail throughout embryonic and imaginal development using confocal laser-scanning microscopy and specific mAb probes. We find(More)
The primary structure of the major embryonic Notch transcript is presented, as determined by sequence analysis of overlapping cDNA clones. The 10,148 bp sequence corresponding to this transcript possesses an 8109 bp open reading frame that potentially codes for a 2703 amino acid protein. We show that this polypeptide contains a repeated structure composed(More)
The Notch locus of Drosophila melanogaster is one of a small number of zygotically acting "neurogenic" genes involved in the correct segregation of neural from epidermal lineages during embryogenesis as well as in other postembryonic developmental events. We have generated antibody probes against three regions of the Notch protein to study the expression of(More)
The objective of this study was to determine if human genotypes of Giardia lamblia could be found in canine companion animals from urban and peri-urban environments in Tucson, Arizona. Canine fecal samples collected from the Humane Society of Southern Arizona between July 2006 and April 2009 were screened for G. lamblia infection using immunofluorescent(More)
This paper presents a method for modelling MEMS components whereby the designer can perform precise electrical, mechanical, and coupled electrical and mechanical simulations. Both surface and bulk micromachined components can be modelled at a geometrical level by defining simplified pseudo processes for a commercial CAD tool such as CovertorWare. The(More)
(1982) Nucleated polymerization of actin from the two ends of microvillar filaments in the intestinal brush border. (1982) Regulation of contractility, cytoskeletal structure and filament assembly in brush borders of the intestinal epithelial cells. A novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in(More)
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