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A calculation program is described by means of which the frequency of any type of relationship in cases of disputable descent (questionable partenity, maternity, parenthood, brother- and sisterhood) using blood group results, can be calculated. Within the scope of forensical practice, the program is above all important in cases in which the alleged father(More)
Frequencies for the genetic polymorphisms of the serum proteins Hp, Tf, Gc, Gm, Inv and Pt are presented for 7 ethnically defined Negroid sub-samples (total n = 918--977, depending on genetic marker system) from South Africa. The results are discussed in terms of previous findings and of factors assumed to have an influence on the distribution of the(More)
OBJECTIVE Fractalkine (CX3CL1) represents the sole member of the so-called CX3C chemokines. In rheumatoid arthritis (RA), functional studies suggest a role for this chemokine in monocyte chemotaxis and angiogenesis in the rheumatoid synovium. We analyzed the expression of fractalkine within different T cell subsets of the peripheral blood and expression of(More)
G-CSF (filgrastim) can effectively mobilize peripheral blood progenitor cells (PBPC) when administered during steady-state hematopoiesis. In this single center study, we compared the effectiveness of two different doses of G-CSF on the mobilization of peripheral blood stem cells in patients with Hodgkin's disease, non-Hodgkin's lymphoma, and cancer of the(More)
In a recent publication, Li and Chakravarti claim to have shown that the paternity index is not a likelihood ratio. They present a method of estimating the prior probability of paternity from a sample of previous court cases on the basis of exclusions and nonexclusions. They propose calculating the posterior probability on the basis of this estimated prior(More)
We investigated the feasibility of mobilizing peripheral blood stem cells (PBSC) with G-CSF alone in 24 patients with multiple myeloma. The median age was 53 years (range 33-62). All patients had stage II/III disease and responded to standard first-line (n = 6) or salvage chemotherapy (n = 18). The median number of previous chemotherapy cycles was 7 (4-18)(More)
  • K Hummel
  • 1975
Blood group systems with a rare second allel are in praxis ineffective and therefore uneconomical because of their low exclusion potency as well as their low serostatistical value. The evidence of exclusion in particular blood group systems is fixed by the German "Richtlinien". With the new German law, however, one has to differentiate between the(More)
  • K Hummel
  • 1984
In cases of disputed parentage the biostatistical information is contained in the frequencies X and Y (as defined by Essen-M oller ); X denotes the hypothesis "paternity", Y the hypothesis "non-paternity". Essen-M oller proposed a probability of paternity which includes both values: W = X/(X + Y) (where X + Y becomes 1). G urtler recommends the ratio X/Y as(More)
We report a large family with an isolated case of Huntington's disease (HD), which is probably the result of a new mutation. The patient developed clinical signs typical of HD at the age of 36. The clinical course of the patient's disease is documented by several clinical admissions over a period of 14 years at present. The family history is strikingly(More)