Klaus Lossnitzer

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In the BIO 8262 inbred strain of cardiomyopathic Syrian hamsters, a latent disturbance of their myocardial calcium metabolism could be evidenced. Whereas the myocardial calcium content of untreated young cardiomyopathic hamsters with prenecrotic hearts did not differ from that of healthy control animals, it was distinctly elevated 6 hours after injection of(More)
Chemical as well as cytophotometric studies were carried out on myocardium of cardiomyopathic hamsters of strain BIO 8262 and of healthy control hamsters of strain CLAC. Our interest was to find out whether the cardiomyopathic hamsters suffer from hypertrophic cardiomyopathy or not. The heart muscle mass was only slightly increased in the older(More)
Myosin of the ventricular myocardium of the cardiomyopathic Syrian hamster and of control animals was analysed using non-dissociating pyrophosphate electrophoresis. Three different myosin isoenzymes exhibiting different Ca2+ activated ATPase activities were demonstrated in the ventricular myocardium of the Syrian hamster. As shown by peptide mapping,(More)
Under ether anesthesia electrocardiograms were derived from Syrian hamsters (strain BIO 8262) suffereing from cardiomyopathy and muscular dystrophy. In addition, ventricular weights and body weight were determined. Young hamsters-not yet showing morphological signs of the cardiomyopathy with the exception of possible left ventricular(More)
Beginning about 30 days after birth, polymyopathic Syrian hamsters of the strain BIO 8262 develop calcifying myocardial necrosis. In the final stage the resorptive granulation tissue is followed by scars with multi-nucleated giant cells containing huge amorphous calcium plaques. The ultrastructural findings reveal the importance of myocardial mitochondria(More)
Hemodynamic data of cardiomyopathic hamsters of the strain BIO 8262 aged 70 days and more than 200 days were compared with those of control groups. Left ventricular systolic pressures and heart rate revealed no great differences between the groups. Left ventricular diastolic pressure was lower in both older groups than in both younger groups. Contractility,(More)