Klaus A. Kuhn

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A seamless support of information flow for increasingly distributed healthcare processes requires to integrate heterogeneous IT systems into a comprehensive distributed information system. Different standards contribute to ease this integration. In a research project focussing on the development of a reference architecture for inter-institutional health(More)
There is an increasing interest in changing information systems to support business processes in a more direct way. This means to actively deliver tasks to be performed to the right persons at the right point in time with the necessary information and application functions needed for performing this task. Process-oriented workflow technology is a very(More)
1. Department of Health and Human Services. Fed. Regist. 75, 61497–61501 (2010). <http://edocket. access.gpo.gov/2010/pdf/2010-24853.pdf> 2. Kozlowski, S. et al. N. Eng. J. Med. 365, 385–388 (2011). 3. Woodcock, J. et al. Nat. Rev. Drug Discov. 6, 437–442 (2007). favors the developer of either the original drug or the follow-on version—most often turning on(More)
OBJECTIVE Bilateral adrenalectomy (BADX) is an important treatment option for patients with Cushing's syndrome (CS). Our aim is to analyze the long-term outcomes, surgical, biochemical, and clinical as well as morbidity and mortality, of patients who underwent BADX. DESIGN A total of 50 patients who underwent BADX since 1990 in two German centers were(More)
OBJECTIVES To present a summary of the state of the art in Health Information Systems (HIS), as discussed during the Heidelberg HIS Working Group Conference, and to examine possible strategies for continuous improvement of the field. METHODS The state of the art in HIS is briefly described, and the historical trends are examined that emerge from a review(More)
BACKGROUND Next generation sequencing has become the core technology for gene discovery in rare inherited disorders. However, the interpretation of the numerous sequence variants identified remains challenging. We assessed the application of exome sequencing for diagnostics in complex I deficiency, a disease with vast genetic heterogeneity. METHODS Ten(More)
To deliver patient-specific advice at the time and place of a consultation is an important contribution to improving clinician performance. Using computer-based decision support on the basis of clinical pathways is a promising strategy to achieve this goal. Thereby integration of IT applications into the clinical workflow is a core precondition for success.(More)
K-anonymization is an important technique for the de-identification of sensitive datasets. In this paper, we briefly describe an implementation framework which has been carefully engineered to meet the needs of an important class of k-anonymity algorithms. We have implemented and evaluated two major well-known algorithms within this framework and show that(More)
BACKGROUND Due to the increasing functionality of medical information systems, it is hard to imagine day to day work in hospitals without IT support. Therefore, the design of dialogues between humans and information systems is one of the most important issues to be addressed in health care. This survey presents an analysis of the current quality level of(More)
OBJECTIVE With the ARX data anonymization tool structured biomedical data can be de-identified using syntactic privacy models, such as k-anonymity. Data is transformed with two methods: (a) generalization of attribute values, followed by (b) suppression of data records. The former method results in data that is well suited for analyses by epidemiologists,(More)