Klas Nordlind

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Atopic eczema symptoms may worsen due to stress. In the present study, the cerebellar cortex of the atopic-like mouse NC/Nga was studied regarding the effect of chronic mild stress on expression of two well-characterized serotonergic receptors (R), 5-HT1A and 5-HT2A. In total 24 mice were used. Sixteen of these mice were subjected to unpredictable stressors(More)
Pirfenidone is currently the only approved therapy for idiopathic pulmonary fibrosis, following studies demonstrating that treatment reduces the decline in lung function and improves progression-free survival. Although generally well tolerated, a minority of patients discontinue therapy due to gastrointestinal and skin-related adverse events (AEs). This(More)
Atopic dermatitis (AD) is a chronic inflammatory skin disease with often severe itch. The aim of this study was to determine the pruritogenic and vascular effect of serotonin (5-hydroxytryptamine; 5-HT) in patients with AD and in healthy controls. A 50 µg dose of 5-HT was injected intradermally into non-lesional skin of 25 patients with AD and 25 healthy(More)
OBJECTIVE To identify pathoaetiological neuroimmune mechanisms in patients with atopic dermatitis (AD) and chronic stress, focusing at nerve density, sensory neuropeptides, and the serotonergic system. METHODS Eleven patients with AD with histories of stress worsening were included. Biopsies from involved and non-involved skin were processed for(More)
The expression of Interleukin-6 (IL-6) was studied in normal dorsal root ganglia (DRG) of juvenile and foetal humans, using immunohistochemistry and in situ hybridization techniques. There was an expression of IL-6-like immunoreactivity in more than 75% out of neuronal cells in the juvenile ganglia with a peripheral localization, and also an expression in(More)
Neuropeptide Y (NPY) concentrations were investigated by radioimmunoassay and immunohistochemistry in a murine model of cutaneous leishmaniasis, using a susceptible (BALB/c) and a resistant (C57BL/6) mouse strain. The analyses were performed on the skin, secondary lymphoid organs and dorsal root ganglia (DRG) at 1, 3, 6 and 9 weeks postinfection. An overall(More)
BACKGROUND Stress is known to worsen the symptoms of atopic eczema (AE). Substance P is likely to play an important role in the development and pathogenesis of AE. OBJECTIVE To examine a possible connection between chronic mild stress and changes in the expression of substance P and its receptor (R) neurokinin (NK) 1 in the skin and stress-related brain(More)
The expression of the sensory neuropeptide calcitonin gene-related peptide (CGRP) in the skin, secondary lymphoid organs and dorsal root ganglia (L4-L6) in Leishmania major-induced inflammation was evaluated by radioimmunoassay. The investigation was conducted on two mouse strains, the susceptible BALB/c and the resistant C57BL/6. The CGRP concentration in(More)
Neuropeptides and monoamines have been found in tissues where immune reactions are initiated such as the skin, gut, and respiratory tract, and in these tissues neuropeptides and monoamines might be involved in the regulation of lymphocyte activation. Studies both in in vitro and in vivo showing that various neuropeptides and monoamines may influence(More)
BACKGROUND Interleukin (IL)-2 plays a central role in T cell-dependent immune responses. OBJECTIVES We conducted this study to determine and compare IL-2 expression in lupoid and usual types of Old World Cutaneous Leishmaniasis (OWCL), using immunohistochemistry. PATIENTS AND METHODS Thirteen paraffin-embedded specimens of lupoid and 12 specimens of(More)