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The authors have investigated intracerebral natural resistance mechanism after tumor transplantation into the brain, by using YAC-1 (Moloney leukemia virus-induced T cell lymphoma of A/Sn mouse origin) and its H-2 negative A. H-2-. It was found that highly immunogenic H-2+ YAC-1 was less tumorigenic than A. H-2- in untreated as well as NK-depleted syngeneic(More)
(C57B1 × DBA)F1 hybrids were more resistant to the inoculation of 103 Rauscher virus-induced, serially propagated RBL-5 cells than syngeneic C57Bl recipients. Resistance was linked toH-2di in the C57Bl backcross. Spleen cells from nonimmune (C57Bl × DBA)F1 hybrids were significantly more reactive against RBL-5 in the natural killer (NK) cytotoxicity test in(More)
The syntaxin 11 (STX11) gene is mutated in a proportion of patients with familial haemophagocytic lymphohistiocytosis (FHL) and exocytosis of cytotoxic granules is impaired in STX11-deficient NK cells. However, the subcellular localization, regulation of expression and molecular function of STX11 in NK cells and other cytotoxic lymphocytes remain unknown.(More)
O u r present unde r s t and ing of the mechanisms involved in act ivat ion, specificity, and restr ict ion of T cells is largely indeb ted to studies of cytotoxic responses of lymphocytes in vitro. Dur ing the course of such studies, several invest igators (1-5) have observed generat ion of effector cells wi th the capac i ty to kill auto logous as well as(More)
Genetic factors are known to influence host resistance to certain tumors . In the mouse, resistance has been linked to the MHC locus on chromosome 17 (1-4) . H-2 genes or other closely linked genes may be responsible, and natural resistance to transplantable lymphomas represents one case where these two possibilities have not been resolved (5) . A distinct(More)
This study addresses the role of MHC class I molecules in the rejection of tumor grafts by SCID mice. Tumor cell lines, their corresponding MHC class I transfectants, and MHC class I-deficient mutants were inoculated to SCID mice. This allowed a study of tumor rejection responses in an environment with normal numbers of natural killer cells but largely(More)
We have identified two mutant cell lines which are not able to present epitopes of influenza virus synthesized in the cytoplasm but can present the same epitope when exposed to it as a peptide in the extracellular medium. The cell lines also have a defect in class-I assembly, with reduced expression of assembled alpha chain: beta 2M heterodimers at their(More)
H-2 antigens from three murine tumor-cell lines (YAC, EL-4 and P815) were solubilized with triton X-100 and separated by SDS-polyacrylamide gel electrophoresis. Proteins were eluted from gel slices and assayed for inhibition by a target-effector binding (TBC) assay. Fractions inhibiting alloimmune T cells also contained serologically detectable H-2(More)
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