Klara Totpal

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Expression of PD-L1, the ligand for T-cell inhibitory receptor PD-1, is one key immunosuppressive mechanism by which cancer avoids eradication by the immune system. Therapeutic use of blocking antibodies to PD-L1 or its receptor PD-1 has produced unparalleled, durable clinical responses, with highest likelihood of response seen in patients whose tumour or(More)
Apo2L/TRAIL is a member of the tumor necrosis factor superfamily and an important inducer of apoptosis. Recombinant human (rhu) Apo2L/TRAIL has been attractive as a potential cancer therapeutic because many types of tumor cells are sensitive to its apoptosis-inducing effects. Nonclinical toxicology studies were conducted to evaluate the safety of(More)
Humoral and cellular immune responses in rhesus macaques infected with human immunodeficiency virus type 2. Detection of point mutations with a modified ligase chain reaction (Gap-LCR). Diminished responsiveness of senescent normal human fi-broblasts to TNF-dependent proliferation and interleukin production is not due to its effect on the receptors or on(More)
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