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Rapid Turnover of Long Noncoding RNAs and the Evolution of Gene Expression
A large proportion of functional sequence within mammalian genomes falls outside protein-coding exons and can be transcribed into long RNAs. However, the roles in mammalian biology of long noncodingExpand
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Extensive compensatory cis-trans regulation in the evolution of mouse gene expression.
Gene expression levels are thought to diverge primarily via regulatory mutations in trans within species, and in cis between species. To test this hypothesis in mammals we used RNA-sequencing toExpand
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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association studyExpand
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Cooperativity and Rapid Evolution of Cobound Transcription Factors in Closely Related Mammals
Summary To mechanistically characterize the microevolutionary processes active in altering transcription factor (TF) binding among closely related mammals, we compared the genome-wide binding ofExpand
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Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways
As exome sequencing gives way to genome sequencing, the need to interpret the function of regulatory DNA becomes increasingly important. To test whether evolutionary conservation of cis-regulatoryExpand
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Dissecting the Within-Africa Ancestry of Populations of African Descent in the Americas
Background The ancestry of African-descended Americans is known to be drawn from three distinct populations: African, European, and Native American. While many studies consider this continentalExpand
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Decoupling of evolutionary changes in transcription factor binding and gene expression in mammals.
To understand the evolutionary dynamics between transcription factor (TF) binding and gene expression in mammals, we compared transcriptional output and the binding intensities for threeExpand
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Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes.
Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-qualityExpand
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Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent
Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There isExpand
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Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains
CTCF binding contributes to the establishment of higher order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). We have carried out anExpand
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