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Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues.

• Klaas Verschueren, Mathias Cobbaut, +4 authors Wim M De Borggraeve
• MedChemComm
• 2017

In this study, we set out to rationally optimize PKD inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold. The lead compound for this study was 1-NM-PP1, which was previously found by us and… (More)

Improved detection of β-N-methylamino-L-alanine using N-hydroxysuccinimide ester of N-butylnicotinic acid for the localization of BMAA in blue mussels (Mytilus edulis).

• Rudolf Andrýs, Javier Zurita, Nadezda Zguna, Klaas Verschueren, Wim M De Borggraeve, Leopold L. Ilag
• Analytical and bioanalytical chemistry
• 2015

β-N-Methylamino-L-alanine (BMAA) is an important non-protein amino acid linked to neurodegenerative diseases, specifically amyotrophic lateral sclerosis (ALS). Because it can be transferred and… (More)

Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues† †Electronic supplementary information (ESI) available. See DOI:…

• Klaas Verschueren, Mathias Cobbaut, +4 authors Wim M De Borggraeve
• 2017

Verschueren Klaasa†, Mathias Cobbautb†, Joachim Demaerela, Lina Saadahb, Arnout R.D. Voetc, Johan Van Lintb and Wim M. De Borggraevea* aDepartment of Chemistry, Molecular Design and Synthesis, KU… (More)

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