Klaas L. Wubs

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Female LOU/M rats, bearing either a cisplatin (cisDDP)-sensitive or -resistant IgM immunocytoma, were sacrificed at 1 or 24 h after cisDDP administration (i.v., 10 mg/kg of body weight). Platinum levels, determined with atomic absorption spectroscopy, were in the order kidney much greater than liver greater than tumor greater than spleen in the 1-h samples.(More)
The use of recombinant bovine somatotropin (rbST) to enhance milk production is approved in several countries, but it is prohibited in the European Union. According to EU legislation, it is necessary to confirm positive screening results prior to enforcement. Although adequate screening assays are available nowadays, development of liquid chromatography(More)
In this study we have investigated the use of liposomes as a drug carrier system for cis-diamminedichloroplatinum (II) (cis-DDP) in order to reduce the nephrotoxicity with preservation of antitumor activity. Liposomes (PC/PS/Chol 10:1:4) were prepared using hydration media containing no or a relatively low concentration of NaCl. It was found that cis-DDP(More)
A simple procedure is described for the enzymic digestion of intact solid tissue samples. The samples are digested in an enzyme suspension containing collagenase and subtilisin Carlsberg without additional grinding or homogenizing. Bacterial growth during digestion is reduced by addition of an antibiotic solution. The resulting digests contain only very(More)
Female LOU/M rats, bearing either a cisplatin (cisDDP)-sensitive or -resistant IgM immunocytoma, were sacrificed at 1 or 24 h after cisDDP administration (i.V., 10 mg/kg of body weight). Platinum levels, deter mined with atomic absorption spectroscopy, were in the order kidney » liver > tumor > spleen in the 1-h samples. In the 24-h samples, more platinum(More)
s of papers Pharmaceutical and Biomedical Analysis Meeting Organized by the Working Group Pharmaceutical and Biomedica Analysis (Werkgroep Farmaceutische en Biomedische Analyse) Oss (the Netherlands), 17 November 1989 Organizin$ committee: Prof. Dr. U.A.T. Brinkman (Amsterdam) Dr. J.J.M. Holthuis (Amsterdam) Dr. J. Paanakker (Oss) Prof. Dr. D.A. Doornbos(More)
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