Klaas Esseling

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Young fish (Oreochromis mossambicus) were exposed to microgravity (micro g) for 9 to 10 days during space missions STS-55 and STS-84, or to hypergravity (hg) for 9 days. Young animals (stages 11-12), which had not yet developed the roll-induced static vestibuloocular reflex (rVOR) at micro g- and hg-onset, and older ones (stages 14-16), which had already(More)
The effects of altered gravitational forces (AGF) on the development of the static vestibulo-ocular reflex (VOR) were investigated in Xenopus laevis tadpoles exposed to hypergravity (1.4g; 3g) or microgravity conditions (German spacelab mission D-2) for 9–10 days. The effects of light conditions during development were also tested by exposing tadpoles to(More)
In 25 rats, an intracerebral hematoma was created in the foreleg area of the motor cortex by injection of 50 microliters blood. After the lesion, 13 were treated with flunarizine and 12 with the solvent. Neurological testing was performed by measuring the running time on a rotating platform. In animals with hemiparesis, the flunarizine group (n = 7) showed(More)
Experiments were performed to answer the question, whether series of generalized tonic-clonic seizures, induced in the awake rat by a local injection of Na-penicillin (PCN) solution into the motor cortex, terminates at the same critical concentration Ct of PCN within the focal area independently of the concentration C0 of PCN injected. Using the PCN(More)
limonene/ozone (Table 2). Ozone production rates ([03]ma × divided by irradiation time) for linalool ranged from 0.32 to 0.39 ppb rain -1 and are comparable to those found by the photooxidation of toluene and isoprene (0.36 to 0.45ppbmin -1) and higher than the corresponding values measured for aand fl-pinene (0.1 to 0.24 ppb min-1). Changes in relative(More)
In awake rats, the time courses of behavioural and cortical interictal hyperactivity patterns were investigated following an injection of the GABA antagonist Na-penicillin (PCN) (125 IU/0.5 microliters) into the olfactory or motor cortex. The cortical EEG was recorded by means of 6 AgAgCl-electrodes, behaviour was videotaped simultaneously. Behavioural(More)
In awake rats, experiments were performed to study early epileptiform events (interictal spike, myoclonic jerk) in relation to a) the strength of the convulsive stimulus, b) the site of the focus, and c) epileptiform experience. For this reason, Na-penicillin G (PCN) was injected either into the motor or visual cortex and, in a second test 2 weeks(More)
1. Experiments were performed to investigate the contribution of diffusion to the termination of PCN induced convulsive (epileptiform) activity in the awake rat. The basic question was whether convulsive activity terminates at the same critical concentration Ct of PCN independently of the concentration Co of PCN injected into the superficial layer of the(More)