Kjetil Unneberg

Learn More
OBJECTIVE To investigate if growth hormone (GH) or its main mediator insulin-like growth factor-1 (IGF-1) alters the response to infusion of live Escherichia coli in injured pigs. DESIGN Controlled experiment. SETTING University laboratory, Norway. SUBJECTS 30 piglets. INTERVENTIONS The response to infusion of Escherichia coli was compared after a(More)
Nineteen patients undergoing elective gastrointestinal surgery were randomised to receive recombination human growth hormone (n = 9) or placebo (n = 10) for the first five postoperative days. All received epidural analgesia and total parenteral nutrition during the same period (energy supply 125% of basal metabolic rate, mean nitrogen (+/- SEM) 5.7 (+/-(More)
OBJECTIVE To study the effects of growth hormone (GH) and insulinlike growth factor 1 (IGF-1) on whole body and gastrointestinal (GI), hepatic, femoral, and renal glutamine (GLN) uptake and release in septic piglets. SUMMARY BACKGROUND DATA The GI metabolism of GLN is impaired during sepsis, and this may contribute to a breakdown of the gut's mucosal(More)
OBJECTIVE To clarify the effects of growth hormone (GH) given three days before and at the start of a standard abdominal operation or at the start of the abdominal operation alone in piglets. DESIGN Randomised experiment. SETTING University hospital, Norway SUBJECTS Twenty-four piglets. INTERVENTIONS GH 24 IU was given intramuscularly for either(More)
Thromboplastin activity of monocytes from blood of seven patients with total hip replacement was investigated. At 24 h and 48 h after surgery, thromboplastin activity was significantly increased compared to the activity before surgery. Thromboplastin activity of endotoxin-stimulated monocytes was significantly increased at 24 h after surgery. There were no(More)
BACKGROUND Insulin-like growth factor 1 (IGF-1) mediates anabolic actions in catabolic states and also influences the immune system. Endogenous IGF-1 production is suppressed in sepsis; replacement therapy is therefore a natural approach to obtain the protein anabolic and potentially immune-stimulating effects of IGF-1. METHODS Twenty-two piglets were(More)
The aim of this study was to assess the influence of growth hormone (GH) in sepsis on the immune system represented by the circulating TNF-levels and the neutrophil leukocytes phagocytic capacity and respiratory burst, 22 piglets were randomized to 3 groups; pretreatment with GH (16 i.u.) before sepsis (n = 8), non-treated septic controls (n = 8), and(More)
Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) may be beneficial against the protein catabolism seen in injury and septicemia. Further understanding of their effects on carbohydrate metabolism is needed. In a septic porcine model receiving total parenteral nutrition, pretreatment with GH or IGF-1 (or no treatment in controls) was followed by(More)
OBJECTIVE To study hemodynamic effects of growth hormone (GH) and its main mediator, insulin-like growth factor-1, in a model of critical illness. DESIGN Randomized experiment in traumatized and septic piglets. MATERIALS AND METHODS Hemodynamics and blood gases before and sustained volume loss during a controlled, fatal hemorrhage were recorded in a GH(More)
Endothelin-1 belongs to a family of potent vasoconstrictors, recently isolated from endothelial cells. Endothelin-1 has a variety of hepatic effects and hepatic clearance from the circulation is important. Elevated plasma concentrations of Endothelin-1 are found after orthotopic liver transplantation and in cirrhosis with ascites. This study in piglets on(More)