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The effects of morphine and fentanyl on respiration and tissue CO2 measured transcutaneously were studied at surface and at 41 bar ambient pressure in conscious, trained rats. Morphine and fentanyl were given in equianalgesic doses i.v., 7 and 0.025 mg/kg, respectively. Fentanyl caused a rapid but brief respiratory depression which was the same at 1 and 41(More)
Sodium benzylpenicillin, cloxacillin, and azlocillin were infused intravenously in awake rats at 1 and 41 bar until they convulsed. The doses necessary to elicit convulsions were significantly lower at 41 than at 1 bar, i.e., with a 24% (P less than 0.0005) lower dose of benzylpenicillin and a 23% lower dose of azlocillin (P less than 0.005). The convulsion(More)
This study investigates the behavioral effects of morphine administration and exposure to high ambient pressure in the formalin test. Rats were simultaneously given formalin (0.1 ml, 5%) in a hind paw, and saline or morphine (2.5-10.0 mg/kg) subcutaneously. They were then exposed to ambient pressure of either 1 or 48 bar (compression rate: 3 bar/min; 1 bar(More)
Convulsant doses of penicillin and elevated ambient pressure of 41 bar enhance the excitability of neurons. Their effects have been studied in neostriatal tissue with methods allowing differentiation between transmitter and metabolic glutamate pools. Levels of glutamate (Glu), glutamine (Gln), aspartate (Asp); γ-aminobutyric acid and taurine were measured(More)
The accuracy of transcutaneous CO2 monitoring with the Kontron CO2 sensor was studied during compression to 41 bar and subsequent decompression. The PCO2 was stable and accurate during the test of the sensor in the pressure chamber, although an increase of 0.1-0.2 kPa during compression was found. The function of the transcutaneous sensor was tested in rats(More)
The anesthetic dose requirement and distribution of 14C-labeled pentobarbital were studied in rats at 1 ATA air and at 71 ATA He-O2. Pentobarbital was infused intravenously at a rate of 5 mg X kg-1 X min-1. The depth of anesthesia was assessed by EEG using the burst suppression of 1-s duration (silent second) as the biological end point. The mean anesthetic(More)
The EEG of rats was studied with power spectrum analysis under compression to 71 ATA with He-O2 and during constant rate infusion of pentobarbital at 71 ATA and at surface. During compression the 1-4 Hz delta activity was increased, and 8-11 Hz alpha, 12-14 Hz spindle, and 16-10 Hz low beta activities were reduced compared to control animal recordings.(More)
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