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β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
It is discovered that the β2-adrenoreceptor (β2AR) is a regulator of the α-synuclein gene (SNCA) and constitutes a potential target for therapies in Parkinson’s disease.
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
It is determined that Epstein-Barr virus infection greatly increased the risk of subsequent multiple sclerosis and that it preceded the development of disease, supporting its potential role in the pathogenesis of multiple sclerosis.
Neurofilament light chain predicts disease activity in relapsing-remitting MS
- Kristin N Varhaug, C. Barro, C. Vedeler
- Medicine, BiologyNeurology: Neuroimmunology & Neuroinflammation
- 28 November 2017
SerumNF-L could be a promising biomarker for subclinical MRI activity and treatment response in RRMS and in clinically stable patients, serum NF-L may offer an alternative to MRI monitoring for sub clinical disease activity.
Sun exposure and multiple sclerosis risk in Norway and Italy: The EnvIMS study
Converging evidence from different measures underlines the beneficial effect of sun exposure on MS risk, and a significant association between infrequent summer outdoor activity and increased MS risk was found in Norway and in Italy.
Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple Sclerosis.
The levels of sNfL were increased 6 years before the clinical onset of multiple sclerosis, indicating that MS may have a prodromal phase lasting several years and that neuroaxonal damage occurs already during this phase.
Preclinical disease activity in multiple sclerosis: A prospective study of cognitive performance prior to first symptom
To prospectively investigate potential signs of preclinical multiple sclerosis (MS) activity and when they are present prior to first symptom using data from a historical cohort.
Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: The EnvIMS study
The findings not only support the hypothesis relating to low vitamin D as a risk factor for MS, but further point to adolescence as an important susceptibility period for adult-onset MS.
Level of education and multiple sclerosis risk after adjustment for known risk factors: The EnvIMS study
Investigating the association between level of education and MS risk adjusting for the known risk factors smoking, infectious mononucleosis, indicators of vitamin D levels and body size suggests factors related to lower socioeconomic status other than established risk factors are associated with MS risk.
Level of education and multiple sclerosis risk over a 50-year period: Registry-based sibling study
Level of education was inversely associated with MS risk, and the estimates were similar in the earliest and latest birth cohorts, and a significant effect modification by parental education was observed.
Diet pattern and prodromal features of Parkinson disease
- Samantha A. Molsberry, Kjetil Bjornevik, K. C. Hughes, B. Healy, M. Schwarzschild, A. Ascherio
- Medicine, PsychologyNeurology
- 19 August 2020
The inverse association between these diet patterns and prodromal PD features is consistent with previous findings and suggests that adherence to a healthy diet may reduce the occurrence of nonmotor symptoms that often precede PD diagnosis.