Kjell Modigh

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Serum levels of progesterone, total testosterone, free testosterone, androstenedione (A2), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), 17-OH-progesterone (17-OHP), and sex hormone binding globulin (SHBG) were measured in the follicular phase, around ovulation, and in the luteal phase of 11 women with severe premenstrual(More)
A double-blind, placebo-controlled trial was undertaken to compare the effects of imipramine and clomipramine in the treatment of panic disorder with or without agoraphobia. The number of dropouts in the placebo-treated group was 7; in the imipramine-treated group, 4; and in the clomipramine treated group, 0. Ten subjects fulfilled the 12 weeks of treatment(More)
Male mice were administered electric convulsive shocks (ECS) once daily for one (ECS×I), three (ECS×III) or seven days (ECS×VII). One (day 1), three (day 3) or six days (day 6) later they received reserpine 10 mg/ kg, followed 2 hours later by clonidine, 1.5 mg/kg, and/or apomorphine, 1.5 mg/kg. Control animals received the same drug treatments but no ECS.(More)
The α-adrenergic mechanisms exert a stimulatory influence on the secretion of growth hormone (GH) in the rat. In the present study the α receptors involved in GH regulation were characterized with respect to subtype. It was also investigated whether the GH response to α receptor agonists can be utilized to assess changes in the responsiveness of central α(More)
The dexamethasone suppression test (DST) was performed in panic disorder (PD) patients with (n = 32) or without (n = 31) agoraphobia and in normal controls (n = 49). Postdexamethasone serum cortisol levels were significantly higher in agoraphobic PD patients (105.3 +/- 19.3 nmol/L) both when compared to PD patients without agoraphobia (47.3 +/- 7.7 nmol/L;(More)
The effects of electroconvulsive shocks administered once daily for 7 days (ECS x VII) on the synthesis, turnover, and uptake of dopamine (DA), noradrenalin (NA), and 5-hydroxytryptamine (5-HT) in rat brains were studied in vivo 1–7 days after the last ECS. The syntheses of catecholamines (CA) and 5-HT were estimated by measuring the accumulation of(More)
The methyl-ester-hydrochloride of p-chlorophenylalanine alone (50 or 150 mg/kg i.p.) and in combination (4×100 mg/kg i.p.) with pargyline (100 mg/kg i.p.) caused a shortening of the ejaculation latencies in male rats and an increase in the number of intromissions per minute. No changes were observed in other components of the sexual behavior including(More)
The effects on GH secretion of reserpine, alpha-methyl-p-tyrosine (alpha-MT), p-chlorophenylalanine (PCPA), and haloperidol were studied in undisturbed, unanesthetized male rats with implanted intraaortic cannulae. The effects of the various drug treatments on motor activity and brain levels of catecholamines (CAs) and 5-hydroxytryptamine (5-HT) as well as(More)
The cerebrospinal fluid (CSF) levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA), the noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), and the dopamine metabolite homovanillic acid (HVA) did not differ significantly in a group of patients with panic disorder (n = 17) as compared to age- and sex-matched normal controls (n =(More)