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ATP:cob(I)alamin adenosyltransferases (ACAs) catalyze the transfer of the 5'-deoxyadenosyl moiety from ATP to the upper axial ligand position of cobalamin in the synthesis of coenzyme B 12. For the ACA-catalyzed reaction to proceed, cob(II)alamin must be reduced to cob(I)alamin in the enzyme active site. This reduction is facilitated through the generation(More)
Mononuclear non-haem iron (NHFe) enzymes catalyse a broad range of oxidative reactions, including halogenation, hydroxylation, ring closure, desaturation and aromatic ring cleavage reactions. They are involved in a number of biological processes, including phenylalanine metabolism, the production of neurotransmitters, the hypoxic response and the(More)
Sediment plugs have occurred 4 times over the last 20 years in the Middle Rio Grande, NM. Starting in the Tiffany area in 1991~1995, and 2005, a sediment plug occurred around the Bosque del Apache Wildlife Refuge in 2008. In order to examine the mechanics of sediment plug formation, analytical and numerical modeling approaches have been adopted. Analytical(More)
Korean people have suffered from floods and droughts year after year. Two-thirds of the Korean peninsula is mountainous and two-thirds of the annual rainfall precipitation is concentrated during the summer season. Water management in Korea requires a lot of caution and state-of-the-art technologies. Korea is ranked 129th in the water stress index in the(More)
The human-type ATP:corrinoid adenosyltransferase PduO from Lactobacillus reuteri (LrPduO) catalyzes the adenosylation of Co(II)rrinoids to generate adenosylcobalamin (AdoCbl) or adenosylcobinamide (AdoCbi+). This process requires the formation of “supernucleophilic” Co(I)rrinoid intermediates in the enzyme active site which are properly positioned to(More)
Binuclear non-heme iron enzymes activate O2 to perform diverse chemistries. Three different structural mechanisms of O2 binding to a coupled binuclear iron site have been identified utilizing variable-temperature, variable-field magnetic circular dichroism spectroscopy (VTVH MCD). For the μ-OH-bridged Fe(II)2 site in hemerythrin, O2 binds terminally to a(More)
Supplementary Figure 1 | X-ray crystallographic structures of SyrB2 resting Fe II active site (substrate-free) coordinated with αKG and Cl – /Br – (taken from ref. 23, main text). a, Overlaid structures of Fe II active sites from both monomeric units (Chains A and B) of SyrB2–Cl (top) and SyrB2–Br (bottom). b, Overlaid structures of Chain B of SyrB2–Cl and(More)