Kiyoshi Hasegawa

Norihiro Kokudo15
Junichi Kaneko9
Yasuhiko Sugawara8
15Norihiro Kokudo
9Junichi Kaneko
8Yasuhiko Sugawara
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Currently, surgical resection is the treatment strategy offering the best long-term outcomes in patients with hepatocellular carcinoma (HCC). Especially for advanced HCC, surgical resection is the only strategy that is potentially curative, and the indications for surgical resection have expanded concomitantly with the technical advances in hepatectomy. A(More)
The nonlinear partial least squares (PLS) method is a nonlinear version of PLS. In this approach, a quadratic inner relation is used instead of the linear inner relation in PLS. Since the quadratic inner relation can be extended to a general form, it is said that the nonlinear PLS method has a high potential for nonlinear modelling. However, few(More)
The GAPLS (GA based PLS) program has been developed for variable selection in QSAR studies. The modified GA was employed to obtain a PLS model with high internal predictivity using a small number of variables. In order to show the performance of GAPLS for variable selection, the program was applied to the inhibitor activity of calcium channel antagonists.(More)
Comparative molecular field analysis (CoMFA) with partial least squares (PLS) is one of the most frequently used tools in three-dimensional quantitative structure-activity relationships (3D-QSAR) studies. Although many successful CoMFA applications have proved the value of this approach, there are some problems in its proper application. Especially, the(More)
Comparative molecular field analysis (CoMFA) has been widely used as a standard three dimensional quantitative structure-activity relationship (3D-QSAR) method. Although CoMFA is a useful technique, it does not always reflect real ligand-receptor interaction. Molecular interactions between the ligand and receptor are mainly occurred near the van der Waals(More)
Proteinprotein interaction (PPI) pockets in a hostguest protein system were predicted using an L-shaped partial least squares (LPLS) method. LPLS is an extension of standard PLS regression, where, in addition to response vector y and regressor matrix X, an extra data matrix Z is constructed which summarizes the background information on X. The regressor(More)
Activity landscapes were used in combination with atom colourings for the visualization of molecular selectivity. Multiple inhibitory activities in the dopamine family were selected in order to derive its molecular selectivity. All molecular structures were mapped in 2D chemical space by preserving the relative distance between any pair of molecules using(More)
Recently, we investigated and proposed the novel molecular alignment method with the Hopfield Neural Network (HNN). Molecules are represented by four kinds of chemical properties (hydrophobic group, hydrogen-bonding acceptor, hydrogen-bonding donor, and hydrogen-bonding donor/acceptor), and then those properties between two molecules correspond to each(More)
In the present study, we investigated the clinicopathologic significance of intratumoral lymphoplasmacytic infiltration in a large cohort of patients with solitary hepatocellular carcinoma (HCC). Based on examination of hematoxylin and eosin-stained sections, significant infiltration was defined as dense lymphoplasmacytic infiltration, either multifocal or(More)