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To examine whether the single nucleotide polymorphism at position +4 of the choline acetyltransferase (ChAT) confers a risk for Alzheimer's disease (AD), we determined the ChAT and the Apolipoprotein (APOE) genotypes of the 246 AD patients and 561 non-demented controls. The ChAT AA genotype was found to confer the risk for AD in concert with the APOE(More)
Transcranial direct current stimulation (tDCS) is a neuromodulation protocol that can facilitate or inhibit cortical excitability in particular areas of the brain. Although recent studies have reported that tDCS can successfully modulate the excitability of various brain sites, outcomes of tDCS were not consistent between subjects even when identical(More)
INTRODUCTION Precise localization of epileptogenic zones is essential for the successful surgical treatment of refractory epilepsy including Lennox-Gastaut syndrome (LGS). The surgical resection areas are generally determined by epileptologists based on diverse neuroimaging modalities; however, exact epileptogenic zones cannot be accurately localized in(More)
We carried out an magnetoencephalography (MEG) study to record cortical responses elicited in the left hemisphere by ending verb phrases, which had syntactic or semantic anomalies, in Korean sentences of subject-object-verb order. Using the high temporal and spatial resolution of MEG, the study was aimed at identifying neural activities that occur during a(More)
While brain computer interface (BCI) can be employed with patients and healthy subjects, there are problems that must be resolved before BCI can be useful to the public. In the most popular motor imagery (MI) BCI system, a significant number of target users (called "BCI-Illiterates") cannot modulate their neuronal signals sufficiently to use the BCI system.(More)
Simultaneous magnetoencephalography (MEG) and electroencephalography (EEG) analysis is known generally to yield better localization performance than a single modality only. For simultaneous analysis, MEG and EEG data should be combined to maximize synergistic effects. Recently, beamformer for simultaneous MEG/EEG analysis was proposed to localize both(More)
BACKGROUND AND PURPOSE The aim of this study was to determine the usefulness of three-dimensional (3D) scalp EEG source imaging (ESI) in partial epilepsy in comparison with the results of presurgical evaluation, magnetoencephalography (MEG), and electrocorticography (ECoG). METHODS The epilepsy syndrome of 27 partial epilepsy patients was determined by(More)
To study the relationship between the varying degrees of cognitive load and long-range synchronization among neural networks, we utilized a dual-task paradigm combining concurrent word recall working memory tasks and oculomotor tasks that differentially activate the common frontoparietal (FP) network. We hypothesized that each dual-task combination would(More)