Kitt Falck Petersen

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The effect of glucagon on the capacity of urea-N synthesis was examined in 24 rats as a function of time. First, the conditions for saturation of urea synthesis under glucagon influence were studied by the kinetics of urea-N synthesis rate in relation to arterial blood alpha-amino-N concentration between 5 and 17 mmol/l in 21 nephrectomized rats given(More)
The effect of the liver on glucose uptake in muscle was studied in the isolated rat hindquarter, perfused with and without an isolated rat liver included in a recirculating system. Glucose uptake in the hindquarter was 0.75 +/- 0.10 mumol.min-1 x 100 g bw-1 (mean and SEM), and increased to 1.30 +/- 0.12 during the period when the liver was included in the(More)
Low birth weight (LBW) is associated with type 2 diabetes and depression, which may be related to prenatal stress and insulin resistance as a result of chronic hypothalamic-pituitary-adrenal (HPA) axis hyperactivity. We examined whether treatment with a selective serotonin reuptake inhibitor [escitalopram (ESC)] could downregulate HPA axis activity and(More)
The in vivo capacity of urea nitrogen synthesis (CUNS) during alanine stimulation was measured within the blood amino acid concentration interval 7.3-11.6 mmol/l, where urea synthesis is at maximum and independent of substrate concentration. Three groups of rats were fed for 14 days, either a low protein diet (8%), a normal diet (17%), or a high protein(More)
1. In the present study the major metabolic pathways of glucose metabolism were determined in isolated liver cells using [2-13C]acetate and 13C magnetic resonance spectroscopy. 2. The relative reaction rates of glucose synthesis to the TCA cycle were determined from the 13C distribution in glucose where the overall 13C enrichment of glucose was 6.41 +/-(More)
Liver regeneration was studied as a function of time after suppression of the normal glucagon response. Rats were given a daily subcutaneous injection of 20 micrograms zincglucagon for 14 days, whereafter a 70% hepatectomy was performed. In the glucagon treated rats the rise in plasma glucagon concentration was diminished after hepatectomy. At intervals(More)
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