Kishore B. Kumar

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This study examined the integrity of hypothalamic-pituitary-adrenal (HPA) axis in clomipramine model of depression. Male rat pups were treated twice daily from postnatal day 5 to 21 with clomipramine (15 mg/kg, s.c.). At three months of age, serum corticosterone level was estimated before and after dexamethasone (100 microg/kg, s.c.) administration and(More)
Several studies in humans have indicated an association between enhanced retrieval of unpleasant events and depressive mood. No analogy has so far been demonstrated in animals, however. The purpose of the present study was to determine the effect of learned helplessness on the retrieval of unpleasant memory in rats. Animals initially exposed to a single(More)
The aim of the present study was to determine the effect of inescapable shock on appetitive and aversive memory retrieval. Rats conditioned in a T-maze with appetitive (10% sucrose) and aversive (2.0 mA) events were subjected, respectively, to inescapable, escapable, and no-shock stress treatments. A retention test conducted 48 hr following exposure to(More)
This study examined whether depletion of central norepinephrine produces an improved retrieval of aversive memories in the same way as pre-exposure to inescapable footshocks, in rats. Animals conditioned in a T-maze with appetitive (10% sucrose) and aversive (2.0 mA footshock) events were given a single dose of DSP-4 (100, 200 or 400 micrograms/rat) or drug(More)
This study investigated the effects of REM (rapid eye movement) sleep deprivation (RSD) on the activity of central cholinergic receptors and passive avoidance retention in rats treated neonatally with clomipramine. Male rat pups treated with clomipramine (15 mg/kg, s.c.) twice daily from postnatal day 5 to 21 were subjected to RSD procedure at three months(More)
Several multi-pass algorithms have been proposed for Association Rule Mining from static repositories. However, such algorithms are incapable of online processing of transaction streams. In this paper we introduce an efficient single-pass algorithm for mining association rules, given a hierarchical classification amongst items. Processing efficiency is(More)
Two commonly used antiepileptic drugs, phenytoin sodium and phenobarbital sodium, were investigated for state-dependency effects at different doses. Male Wistar strain rats trained to a criterion in an inhibitory avoidance task and a food-motivated T-maze task under varying drug and nondrug states were subjected to retention tests 24 and 48 h, respectively,(More)
The study of toxicity of metals on the enzyme activity in the Hydrilla plant indicated that in general there is induction or inhibition in enzyme activity. The enzymes studied here in relation Hg and Cd toxicity like catalase, peroxidase and polyphenol oxidase found in the plant responded differently to the metal treatment. Catalase and polyphenol oxidase(More)
Changes in the activities of the enzymes catalase and peroxidase were studied in the excised leaves of ragi (Eleusine coracana Gaertn. cv PR 202) plants belonging to different ages. Catalase exhibited a positive and peroxidase a negative correlation with the changes in chlorophyll. Catalase and peroxidase were negatively correlated with each other.(More)