Kirti Kumar Tiwari

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Caffeine is used to prevent bronchopulmonary dysplasia (BPD) in premature neonates. Hyperoxia contributes to the development of BPD, inhibits cell proliferation and decreases cell survival. The mechanisms responsible for the protective effect of caffeine in pulmonary oxygen toxicity remain largely unknown. A549 and MLE 12 pulmonary epithelial cells were(More)
GDF15 (growth and differentiation factor 15) is a secreted cytokine, a direct target of p53 and plays a role in cell proliferation and apoptosis. It is induced by oxidative stress and has anti-apoptotic effects. The role of GDF15 in hyperoxic lung injury is unknown. We tested the hypothesis that GDF15 will be induced in vitro, in a model of pulmonary oxygen(More)
In this paper we present an approach that combines the DFD with the UML diagrams. DFD is a structured approach which provides the functional view of the system whereas UML is an object oriented approach provides the structural view of the embedded system. Structured methods are very commonly used by the developers and if there is need to expand the(More)
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