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Allergy and Asthma: What 'drives' IL-4 versus IL-13 signalling?
crucially involved in the development of allergic responses through their induction of T helper 2 (TH2) cells and promotion of IgE production. Both of these cytokines use the common γ-chainExpand
  • 12
  • 1
Cell adhesion: Integrating the integrin response
  • Kirsty Minton
  • Medicine, Biology
  • Nature Reviews Molecular Cell Biology
  • 12 June 2013
  • 10
  • 1
Inflammasomes: Ubiquitin lines up for inflammasome activity
  • Kirsty Minton
  • Biology, Medicine
  • Nature Reviews Immunology
  • 1 August 2014
Linear ubiquitylation of the adaptor protein ASC regulates interleukin-1β production by the NLRP3 inflammasome.
  • 6
  • 1
Macrophages: A transcription factor to call their own
  • Kirsty Minton
  • Biology, Medicine
  • Nature Reviews Immunology
  • 25 January 2011
expanding list of T cell subsets and their defining transcription factors, macrophages are let in on the act by new research showing that interferon regulatory factor 5 (IRF5) is a subsetdefiningExpand
  • 7
  • 1
Viperin breaks viral chains
  • Kirsty Minton
  • Chemistry, Medicine
  • Nature Reviews Immunology
  • 27 June 2018
The antiviral protein viperin catalyses the production of a small molecule inhibitor of viral RNA polymerization.
  • 3
  • 1
ILC3s take control in small intestine
  • Kirsty Minton
  • Biology, Medicine
  • Nature Reviews Immunology
  • 12 April 2019
This study identifies a role for group 3 innate lymphoid cells in IL-2 production in the small intestine to maintain intestinal homeostasis through effects on regulatory T cells.
  • 2
  • 1
Cell migration: Coordinating calcium signalling
  • Kirsty Minton
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 21 February 2014
Directed cell migration requires the coordinated activities of Ca2+, DAG, PMCA and STIM1 in a polarized manner in leader cells.
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Granulocytes: Eosinophils enable the antitumour T cell response
  • Kirsty Minton
  • Medicine, Biology
  • Nature Reviews Immunology
  • 1 June 2015
Tumour-associated eosinophils support CD8+ T cell-mediated rejection through chemoattraction and vascular normalization.
  • 10
Extracellular matrix: Preconditioning the ECM for fibrosis
  • Kirsty Minton
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 12 November 2014
Increased organization of the ECM mediated by myofibroblast remodelling pre-conditions for TGFβ activation.
  • 13
Mitosis: Microtubule nucleation branches out
  • Kirsty Minton
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 13 March 2013
Generating the mitotic spindle requires precise spatial and temporal regulation of microtubule nucleation. Vale and colleagues provide the first direct visualization of branching nucleation ofExpand
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