Kirsty F. Nahm

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The authors report the clinical and postmortem neuropathologic findings of two patients, one with Parkinson disease (PD) and one with dementia with Lewy bodies (DLB), both of whom initially sought treatment for isolated autonomic failure. These cases suggest that neurodegeneration in PD and DLB may begin outside the CNS in autonomic postganglionic neurons,(More)
The sympathetic nervous system is essential to maintaining blood pressure homeostasis. Of critical importance are peripheral and central catecholaminergic neurons. During orthostatic stress, chromaYn granules of the adrenal medulla and synaptic vesicles of peripheral sympathetic neurons supply catecholamines which sustain arterial pressure. In the(More)
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