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Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
- J. Nangalia, C. Massie, +49 authors A. Green
- Medicine, Biology
- The New England journal of medicine
- 18 December 2013
BACKGROUND Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with nonmutated JAK2 is… Expand
Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.
UVB-induced lesions in mammalian cellular DNA can, through the process of mutagenesis, lead to carcinogenesis. However, eukaryotic cells have evolved complex mechanisms of genomic surveillance and… Expand
The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene
- Y. W. Kong, I. Cannell, +9 authors Martin Bushell
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 1 July 2008
MicroRNAs (miRNAs) are noncoding RNAs that base pair imperfectly to homologous regions in target mRNAs and negatively influence the synthesis of the corresponding proteins. Repression is mediated by… Expand
A novel method for poly(A) fractionation reveals a large population of mRNAs with a short poly(A) tail in mammalian cells
- H. Meijer, M. Bushell, +4 authors C. D. de Moor
- Biology, Medicine
- Nucleic acids research
- 1 October 2007
The length of the poly(A) tail of an mRNA plays an important role in translational efficiency, mRNA stability and mRNA degradation. Regulated polyadenylation and deadenylation of specific mRNAs is… Expand
OP0186 Immune Complex Bound U1 and Y1 RNA Correlates with Interferon-Stimulated Gene Expression and Disease Activity: An Observational Study of Sysytemic Lupus Erythematosus Patients
Background Immune complexes (ICs) containing RNA are thought to play a central role in driving interferon (IFN) production and systemic inflammation in systemic lupus erythematosus (SLE) via… Expand