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Hematopoietic stem cells (HSCs) originate within the aortic-gonado-mesonephros (AGM) region of the midgestation embryo, but the cell type responsible for their emergence is unknown since critical hematopoietic factors are expressed in both the AGM endothelium and its underlying mesenchyme. Here we employ a temporally restricted genetic tracing strategy to(More)
SUMMARY Maintenance of single-layered endothelium, squa-mous endothelial cell shape, and formation of a patent vascular lumen all require defined endothe-lial cell polarity. Loss of b1 integrin (Itgb1) in nascent endothelium leads to disruption of arterial endothe-lial cell polarity and lumen formation. The loss of polarity is manifested as cuboidal-shaped(More)
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