BACKGROUND Pannexin-1 (Panx1) forms an anion-selective channel with a permeability up to ~1 kDa and represents a non-lytic, non-vesicular ATP release pathway in erythrocytes, leukocytes and neurons. Related connexin gap junction proteins have been reported in platelets; however, the expression and function of the pannexins remain unknown. OBJECTIVE To… (More)
Several cell types develop extensive plasma membrane invaginations to serve a specific physiological function. For example, the megakaryocyte demarcation membrane system (DMS) provides a membrane reserve for platelet production and muscle transverse (T) tubules facilitate excitation:contraction coupling. Using impermeant fluorescent indicators, capacitance… (More)
Ligand-gated ion channels on the cell surface are directly activated by the binding of an agonist to their extracellular domain and often referred to as ionotropic receptors. P2X receptors are ligand-gated non-selective cation channels with significant permeability to Ca(2+) whose principal physiological agonist is ATP. This chapter focuses on the… (More)
The present study examined whether popping air capsules affects students' state anxiety. One group of university students were asked to pop air capsules for 5 min. (experimental group); another group did nothing (the control group). Both groups were tested on the State-Trait Anxiety Inventory. Analyses showed that there was a difference in mean State… (More)
After listening to 2 stories, William's Doll and Ira Sleeps Over, 2 groups of kindergarten students (22 boys and 27 girls) were questioned about their attitudes toward the nontraditional male roles depicted. A comparison with a 1975 study by Styer suggests that both genders are more accepting of literature portraying boys in nontraditional ways.