Kirill O. Eremin

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This review considers modern data on the mechanisms underlying the neuroprotective effect of the neurosteroid vitamin D3 and its receptors in the nervous system. Special attention is paid to Ca2+ regulation, stimulation of neurotrophin release, interaction with reactive oxygen and nitrogen species, and neuroimmunomodulatory effects of calcitriol, the main(More)
Corticotrophin (ACTH) and its analogues, particularly Semax (Met-Glu-His-Phe-Pro-Gly-Pro), demonstrate nootropic activity. Close functional and anatomical links have been established between melanocortinergic and monoaminergic brain systems. The aim of present work was to investigate the effects of Semax on neurochemical parameters of dopaminergic- and(More)
Short-term effects of the synthetic nootropic peptide Semax on the content and metabolism of monoamines in the brain of C57/Bl 6 mice and Sprague–Dawley rats were studied. Intraperitoneal injection of Semax at a dose of 0.15 mg/kg caused an increase in the tissue concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in the hypothalamus and striatum of mice(More)
The peptide Semax (MEHFPGP), which is an analogue of the ACTH (4–10) fragment, has a wide spectrum of activity in the nervous system of mammals, including humans. Using a model of neurotoxicity induced by hydroxydopamine, we studied the ability of Semax to prevent the death of tyrosine hydroxylase-positive neurons in a primary mixed neuroglial cell culture(More)
The effect of antiracetam (AN), a nootropic drug, which is one of the modulators of glutamate receptors of the AMPA type, in relation to amphetamine effects on locomotor activity as well as on the content of noradrenalin, dopamine, serotonin, and their metabolites in frontal cortex, hippocampus, hypothalamus, and striatum, was studied in C57/bl mice. AN, at(More)
The synthetic peptide semax (a fragment of ACTH 4-7 Pro-Gly-Pro) enhances the release of extracell dopamine (DA) induced by D-amphetamine (5 mg/kg) in the striatum of Spraig-Dowley (SD) rats and increases the locomotor activity stimulated by D-amphetamine (2 mg/kg) in C57/BL6 mice. The basal content of DA, 3,4-dihydroxyphenylacetic acid (DHPAA), and(More)
Properties of AMPA type glutamate receptors widely presented within mammalian central nervous system are reviewed. AMPA receptors belong to ionotropic subclass of glutamate receptors and participate in fast excitatory glutamatergic transmission in the brain. Molecular structure of AMPA receptors consists of several subunits (GluRA1-GluRA4), which display(More)
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