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Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the identified somatic mutations in 94 T-cell acute lymphoblastic leukaemia cases. ETP ALL was characterized by activating mutations in genes regulating(More)
DNA codeword design has been a fundamental problem since the early days of DNA computing. The problem calls for finding large sets of single DNA strands that do not crosshybridize to themselves, to each other or to others' complements. Such strands represent so-called domains, particularly in the language of chemical reaction networks (CRNs). The problem(More)
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