Learn More
The tectorial membrane (TM) is a polyelectrolyte gel. Hence, its chemical, electrical, mechanical, and osmotic properties are inextricably linked. We review, integrate, and interpret recent findings on these properties in isolated TM preparations. The dimensions of the TM in alligator lizard, chick, and mouse are sensitive to bath ion concentrations of(More)
The equilibrium stress-strain relation and the pore radius of the isolated tectorial membrane (TM) of the mouse were determined. Polyethylene glycol (PEG), with molecular mass (MM) in the range 20-511 kDa, added to the TM bathing solution was used to exert an osmotic pressure. Strain on the TM induced by isosmotic PEG solutions of different molecular masses(More)
The solid component of the tectorial membrane (TM) is a porous matrix made up of the radial collagen fibers and the striated sheet matrix. The striated sheet matrix is believed to contribute to shear impedance in both the radial and longitudinal directions, but the molecular mechanisms involved have not been determined. A missense mutation in Tecta, a gene(More)
The tectorial membrane (TM) has a significantly larger stiffness in the radial direction than other directions, a prominent mechanical anisotropy that is believed to be critical for the proper functioning of the cochlea. To determine the molecular basis of this anisotropy, we measured material properties of TMs from mice with a targeted deletion of Col11a2,(More)
The vertebrate sense of hearing relies on a series of mechanical processes that deflect the sensory bundles of hair cells in the cochlea. Overlying these bundles is an acellular gel called the tectorial membrane (TM), which is believed to play a critical mechanical role in cochlear function. A variety of recent studies have shown that genetic changes to(More)
Current designs for nuclear fusion reactors call for the use of hydrogen isotopes deuterium and tritium as the fuel for the energy producing fusion reactions. Deuterium is plentiful in nature, but tritium undergoes radioactive decay with a half-life of 12 yrs and does not occur naturally. The use of tritium must be carefully controlled due to its cost and(More)
In mammals sound is coupled to the inner ear through a common set of structures, which vary in their configuration among species and individuals. Our goal is to understand the relationships between the structure and acoustic function of the ear. This knowledge can be applied (a) to suggest the evolutionary processes that produced these structural(More)
  • 1