Kinga Salat

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Recently we have shown that 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one dihydrochloride (LPP1) is an antinociceptive and local anesthetic agent in rodents. Below an extended study of the pharmacological activity of LPP1 is described. In vitro LPP1 has no affinity for GABA(A), opioidergic μ and serotonergic 5-HT(1A) receptors. The(More)
Drug interactions are an important issue of efficacious and safe pharmacotherapy. Although the use of drug combinations carries the potential risk of enhanced toxicity, when carefully introduced it enables to optimize the therapy and achieve pharmacological effects at doses lower than those of single agents. In view of the development of novel analgesic(More)
Antiepileptic drugs are commonly used for many therapeutic indications, including epilepsy, neuropathic pain, bipolar disorder and anxiety. Accumulating data suggests that many of them may lower the seizure threshold in men. In the present paper we deal with the possibility of using Support Vector Regression (SVR) to forecast the proconvulsant activity of(More)
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