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  • Influence
Cutting Edge: Novel Function of B Cell-Activating Factor in the Induction of IL-10–Producing Regulatory B Cells
Although B cells have been shown to possess a regulatory function, microenvironmental factors or cytokines involved in the induction of regulatory B cells remain largely uncharacterized. BExpand
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IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation.
IL-10-producing CD1d(hi)CD5(+) B cells, also known as B10 cells, have been shown to possess a regulatory function in the inhibition of immune responses, but whether and how B10 cells suppress theExpand
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Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production.
OBJECTIVE An altered phenotype and dysfunction of natural killer (NK) cells have been observed in patients with rheumatoid arthritis. The aim of this study was to determine whether dysregulated NKExpand
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Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis.
B cell-activating factor (BAFF), a member of tumor necrosis factor family cytokines, has been shown to enhance the maturation and survival of peripheral B cells. While BAFF is implicated inExpand
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Th17 cells play a critical role in the development of experimental Sjögren's syndrome
  • Xiang Lin, Ke Rui, +9 authors L. Lu
  • Biology, Medicine
  • Annals of the rheumatic diseases
  • 26 February 2014
Objective Although Th17 cells have been increasingly recognised as an important effector in various autoimmune diseases, their function in the pathogenesis of Sjögren's syndrome (SS) remains largelyExpand
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Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response.
OBJECTIVE To determine the role of leptin in modulating Th17 cell response and joint inflammation in mice with collagen-induced arthritis (CIA). METHODS Leptin receptor expression on T cells wasExpand
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A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection
Interleukin-17 (IL-17), a member of the IL-17 cytokine family, plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung. Although there is increasingExpand
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Glucocorticoid-induced tumor necrosis factor receptor family-related protein exacerbates collagen-induced arthritis by enhancing the expansion of Th17 cells.
Rheumatoid arthritis (RA), a chronic autoimmune form of inflammatory joint disease, progressively affects multiple joints with pathological changes in the synovia, cartilage, and bone. NumerousExpand
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Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow
Increasing evidence indicates a role of leptin in immune response, but it remains largely unclear whether leptin signaling is involved in regulating NK cell development in the bone marrow (BM). InExpand
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Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow.
OBJECTIVE Hox genes are involved in hematopoietic lineage commitment and differentiation. In this study, we investigated the roles of Hoxb3 in hematopoiesis by examining the phenotypes of a Hoxb3Expand
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