Kin Fong Lei

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A perfusion three-dimensional (3D) cell culture microfluidic chip has been developed for real-time and non-invasive impedimetric monitoring of cell proliferation and chemosensitivity. In this study, human oral cancer cells (OEC-M1) were encapsulated in 3D agarose scaffold and cultured in a miniaturized chamber under perfusion of tested substance. This(More)
In this study, fine bubbles were successfully generated and used as a simple, low-cost driving force for mixing fluids in an integrated microfluidic bead-based enzyme-linked immunosorbent assay (ELISA) to rapidly and quantitatively detect apolipoprotein A1 (APOA1), a biomarker highly correlated with bladder cancer. A wooden gas diffuser was embedded(More)
Because of intensive developments in recent years, the microfluidic system has become a powerful tool for biological analysis. Entire analytic protocols including sample pretreatment, sample/reagent manipulation, separation, reaction, and detection can be integrated into a single chip platform. A lot of demonstrations on the diagnostic applications related(More)
In this paper, we present a low complexity and memory-less algorithm for angle calculations of a system using 3-axis accelerometers. Accelerometers have been widely used to determine the inclination or tilt of a system where the net acceleration or force on a system over time is gravity. However, the angle calculations are complicated and most of the work(More)
A polymer based vortex micropump fabricated by micro molding replication technique is described in this paper. The optically transparent and biocompatible material used to fabricate the micropump will enable the pump to be applied on many biomedical and chemical analyses applications. Fluid transmission of the vortex micropump is driven by the(More)
This paper presents the preliminary design and experimental results of a standard AA size vibration-induced micro energy transducer which is integrated with a power-management circuit. The transducer is a spring mass system which uses SU-8 molding and MEMS electroplating technologies fabricated copper springs to convert mechanical energy into electrical(More)
Blood coagulation is an extremely complicated and dynamic physiological process. Monitoring of blood coagulation is essential to predict the risk of hemorrhage and thrombosis during cardiac surgical procedures. In this study, a high throughput microfluidic chip has been developed for the investigation of the blood coagulation process under temperature and(More)