Kimon Frousios

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BACKGROUND Amyloidoses are a group of usually fatal diseases, probably caused by protein misfolding and subsequent aggregation into amyloid fibrillar deposits. The mechanisms involved in amyloid fibril formation are largely unknown and are the subject of current, intensive research. In an attempt to identify possible amyloidogenic regions in proteins for(More)
<i>Motivation:</i> The constant advances in sequencing technology are turning whole-genome sequencing into a routine procedure, resulting in massive amounts of data that need to be processed. Tens of gigabytes of data in the form of short reads need to be mapped back to reference sequences, a few gigabases long. A first generation of short read alignment(More)
This paper deals with the approximate string-matching problem with Hamming distance and a single gap for sequence alignment. We consider an extension of the approximate string-matching problem with Hamming distance, by also allowing the existence of a single gap, either in the text, or in the pattern. This problem is strongly and directly motivated by the(More)
BACKGROUND The availability of fully sequenced genomes and the implementation of transcriptome technologies have increased the studies investigating the expression profiles for a variety of tissues, conditions, and species. In this study, using RNA-seq data for three distinct tissues (brain, liver, and muscle), we investigate how base composition affects(More)
Several studies on adult tissues agree on the presence of a positive effect of the genomic and genic base composition on mammalian gene expression. Recent literature supports the idea that during developmental processes GC-poor genomic regions are preferentially implicated. We investigate the relationship between the compositional properties of the(More)
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