Kimiko Yamakawa

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To assess the relationship between relatively severe hereditary hypercholesterolemia with Achilles tendon xanthomas and the defect of the low density lipoprotein (LDL) receptor gene, family studies were carried out in 17 hypercholesterolemic families. In 16 out of the 17 families, hypercholesterolemia co-segregated with four different gross rearrangements,(More)
The perception and production boundaries between a fricative [s] and an affricate [ts] in Japanese were investigated to clarify the relationship between them. Regression and discriminant analyses revealed that the perception and production boundaries between [s] and [ts] were represented by very similar linear functions defined by the variables of rise(More)
The low-density lipoprotein (LDL) receptor genes from 18 unrelated Japanese heterozygotes and 1 homozygote with classical familial hypercholesterolemia were analyzed by Southern blot hybridization using fragments of the human LDL receptor cDNA as probes. Four different deletion mutations were detected among 20 mutant LDL receptor genes (20%); they were(More)
The low density lipoprotein (LDL) receptor gene was analyzed in 67 unrelated healthy Japanese and 38 members of six consecutive families with familial hypercholesterolemia (FH) by Southern blot hybridization with TaqI, an LDL receptor cDNA fragment containing exons 1 to 8 being used as a probe. A new TaqI RFLP at the LDL receptor locus was detected with(More)
SummaryTo search for a linkage marker for the putative deleterious atherogenic gene in the apo AI-CIII-AIV gene complex in Japanese, apo CIII Sst-I genotypes and apo AI Msp-I genotypes were investigated in 69 Japanese myocardial infarction survivors, using genomic hybridization analysis, and compared with the genotypes in 82 healthy subjects. Unlike the(More)
SummaryApolipoprotein (apo) CIII Sst-I genotypes and apo AI Msp-I genotypes were investigated in 82 unrelated healthy Japanese, using genomic hybridization analysis with a 2.2 kb fragment of the human apo AI gene. The frequencies of the S2 and M2 alleles were 0.34 and 0.40, respectively, and much higher than those in Caucasians. The alleles identified by(More)
SummaryQualitative and quantitative differences between the EsD 7 and EsD 1 subunits are analysed by two-dimensional gel electrophoresis. The molecular weight of the EsD 7 subunit is slightly smaller than that of the EsD 1 subunit. However, the pI of the EsD 7 subunit is indistinguishable from that of EsD 1 subunit. In the heterozygote with EsD 7-1, the(More)
SummaryHuman apolipoprotein (apo) E plays an important role in the metabolism of cholesterol and other lipids. Apo E5 and apo E7 are genetic variants of apo E and have been detected in about 5% of Japanese patients with hyperlipidemia and ischemic heart disease. The existence of apo E5 and apo E7, however, had not been reported in apparently healthy(More)
The purpose of this study is to visualize the similarities between speech corpora. Speech data are indispensable for promoting speech research. A wide variety of speech corpora has recently been developed in many countries. Corpus diversification has given users many choices for corpus selection. In order for users to easily utilize these various corpora,(More)
It is difficult for the Japanese learners to perceive and produce the morae with devocalized vowels. To make it easier for the Japanese learners to acquire them, we investigate how Japanese native speakers perceive them. Usually the first vowel of the Japanese word ‘susugi’(rinse) disappears, and so the pronunciation of ‘susugi’ is not [susugi] but [ssugi].(More)