Kimberly L. Fife

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To discover drugs lowering PrPSc in prion-infected cultured neuronal cells that achieve high concentrations in brain to test in mouse models of prion disease and then treat people with these fatal diseases. We tested 2-AMT analogs for EC50 and PK after a 40 mg/kg single dose and 40–210 mg/kg/day doses for 3 days. We calculated plasma and brain AUC, ratio of(More)
During the past year, exciting progress has been made in elucidating the pathogenesis of Kaposi's sarcoma (KS). It has been a major focus of research since an aggressive form of the disease was diagnosed in homosexual men in the USA (Friedman-Kien et al., 1981), heralding the AIDS epidemic. Before 1981, three different clinical expressions of the disease(More)
BACKGROUND The detection of occult bone metastases is a key factor in determining the management of patients with renal cell carcinoma (RCC), especially when curative surgery is considered. This prospective study assessed the sensitivity of (18)F-labelled sodium fluoride in conjunction with positron emission tomography/computed tomography ((18)F-NaF PET/CT)(More)
Basal cell carcinoma (BCC) is a common malignancy with a good prognosis in the majority of cases. However, some BCC patients develop a more advanced disease that poses significant management challenges. Such cases include locally advanced, recurrent or metastatic BCC, or tumours that occur in anatomical sites where surgical treatment would result in(More)
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