Kimberly Hales

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Axonal injury is considered the major cause of disability in patients with multiple sclerosis (MS), but the underlying effector mechanisms are poorly understood. Starting with a proteomics-based approach, we identified neurofascin-specific autoantibodies in patients with MS. These autoantibodies recognize the native form of the extracellular domains of both(More)
Paranodal junctions of myelinated nerve fibers are important for saltatory conduction and function as paracellular and membrane protein diffusion barriers flanking nodes of Ranvier. The formation of these specialized axoglial contacts depends on the presence of three cell adhesion molecules: neurofascin 155 on the glial membrane and a complex of Caspr and(More)
There is an ongoing controversy regarding the role of gender in modulating components of the human visual-evoked potential (VEP) and event-related potentials (ERPs). Our aim was to further characterize the role of gender on VEPs, ERPs and response performance in an object recognition task. We recorded VEPs and reaction time (RT) in a paradigm wherein(More)
Several recent studies have established a role for estrogens in ameliorating specific neurodegenerative disorders, mainly those associated with the cholinergic neurons of the basal forebrain and their targets in the cortex and hippocampus. We have previously demonstrated that endogenous and exogenous application of the neurosteroid dehydroepiandrosterone(More)
A mutant polyoma virus (TT340), which replicates in F9 embryonal carcinoma (EC) cells and contains 2500 base pairs (bp) of additional DNA located in the early noncoding region of the genome, was analyzed to determined the DNA origin of the mutant insertion. Two fragments, representing repeated units of the 2500-bp insert, were isolated from TT340, labeled,(More)
NEURONAL AND MOLECULAR ADAPTATIONS OF GABA NEURONS IN THE VENTRAL TEGMENTAL AREA TO CHRONIC ALCOHOL Kimberly Hales Department of Physiology and Developmental Biology Master of Neuroscience The purpose of this thesis project was to examine the effects of chronic alcohol on the excitability and molecular adaptation of GABA neurons of the ventral tegmental(More)
The host restriction imposed on polyoma virus by embryonal carcinoma cells can be circumvented by mutations in the enhancer region of the viral genome. In addition, expression of the early viral genes can be induced by differentiating cells transfected with purified viral DNA. Although no host-range mutants of SV40 have been isolated, expression of T(More)
Paranodal junctions that flank nodes of Ranvier contain a cytoskeleton specialized to prevent membrane protein diffusion in and out of the nodes. This week Ogawa et al. used three known paranodal cell adhesion molecules to fish out additional paranodal molecules. As starting material, the authors isolated optic nerve membranes enriched in glial protein(More)
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