Kimberly A Agnello

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OBJECTIVE To evaluate effects of zoledronate on markers of bone metabolism in dogs after transection of the cranial cruciate ligament (CrCL). ANIMALS 21 adult dogs. PROCEDURE Unilateral CrCL transection was performed arthroscopically. Dogs were allocated to 3 groups (control group, low-dose zoledronate [10 microg/kg, SC, q 90 d for 12 months], and(More)
OBJECTIVE To evaluate the use of a locking compression plate (LCP) with monocortical screw purchase for stabilization of the canine cervical spine. STUDY DESIGN Experimental study. ANIMALS Cadaveric canine cervical spine specimens (n = 7). METHODS Flexion and extension bending moments were applied to canine cadaveric specimens (C3-C6) in 4-point(More)
OBJECTIVE To describe the Single port access (SPA) laparoscopic entry technique for canine ovariectomy (OVE), report complications, and outcomes. STUDY DESIGN Pilot study. ANIMALS Intact female dogs (n = 6). METHODS With owner consent, 6 intact female dogs had SPA laparoscopic OVE. Data, including signalment, surgical time (from incision to completion(More)
Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium-permeable nonselective cation channel, expressed on the peripheral and central terminals of small-diameter sensory neurons. Prolonged calcium influx induced by RTX causes(More)
OBJECTIVE To evaluate in vivo effects of tepoxalin, an inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), on prostaglandin (PG) and leukotriene production in osteoarthritic dogs. ANIMALS 7 mixed-breed adult dogs with chronic unilateral arthritis of a stifle joint. PROCEDURE Dogs were treated in accordance with a randomized 3-way crossover design.(More)
OBJECTIVE To evaluate frequency, severity, and location of patellofemoral (PF) osteoarthritis (OA) in dogs with naturally occurring cranial cruciate ligament (CCL) disease. STUDY DESIGN Cross-sectional observational study. ANIMALS Dogs (n = 40; stifles, 44). METHODS Stifle arthroscopic video recordings and radiographs were performed. Cartilage(More)
BACKGROUND Substance P-saporin (SP-SAP), a chemical conjugate of substance P and a recombinant version of the ribosome-inactivating protein, saporin, when administered intrathecally, acts as a targeted neurotoxin producing selective destruction of superficial neurokinin-1 receptor-bearing cells in the spinal dorsal horn. The goal of this study was to(More)
OBJECTIVE To determine the incidence of pathological fractures associated with appendicular primary bone tumors in dogs managed medically and to identify potential risk factors at the time of radiographic diagnosis that may be associated with eventual pathological fracture. DESIGN Retrospective case series. ANIMALS 84 dogs with primary long bone(More)
Tetracyclines have been shown to regulate matrix metalloproteinase (MMP) expression in numerous cell types with various periodontal disease models. MMP-13, or collagenase-3, has been shown to be induced by a number of osteotropic cytokines and hormones in osteoblastic cells. In this study, we studied MMP-13 gene expression and regulation in osteoblasts by(More)