Learn More
foxd3 encodes a winged helix/forkhead class transcription factor expressed in the premigratory neural crest cells of many vertebrates. We have investigated the function of this gene in zebrafish neural crest by a loss of function approach using antisense morpholino oligonucleotides and immunostaining for Foxd3 protein. Knockdown of Foxd3 expression produces(More)
XML data projection (or pruning) is one of the main optimization techniques recently adopted in the context of main-memory XML query-engines. The underlying idea is quite simple: given a query <i>Q</i> over a document <i>D</i>, the subtrees of <i>D</i> not necessary to evaluate <i>Q</i> are pruned, thus obtaining a smaller document <i>D</i>'. Then <i>Q</i>(More)
A large fraction of an XML document typically consists of text data. The XPath query language allows text search via the equal, contains, and starts-with predicates. Such predicates can be efficiently implemented using a compressed self-index of the document's text nodes. Most queries, however, contain some parts querying the text of the document, plus some(More)
Ligand binding is a vital component of any pharmacologist's toolbox and allows the detailed investigation of how a molecule binds to its receptor. These studies enable the experimental determination of binding affinity of labelled and unlabelled compounds through kinetic, saturation (Kd ) and competition (Ki ) binding assays. Traditionally, these studies(More)
Ketone bodies , β-hydroxybutyrate (BHB) and acetoacetate support mammalian survival during states of energy deficit by serving as alternative source of ATP 1. BHB levels are elevated during starvation, high-intensity exercise or by the low carbohydrate ketogenic diet 2. Prolonged caloric Users may view, print, copy, and download text and data-mine the(More)
We present a calculus for processing semistructured data that spans differences of application area among several novel query languages, broadly categorized as "NoSQL". This calculus lets users define their own operators, capturing a wider range of data processing capabilities, whilst providing a typing precision so far typical only of primitive hard-coded(More)
A large fraction of an XML document typically consists of text data. The XPath query language allows text search via the equal, contains, and starts-with predicates. Such predicates can efficiently be implemented using a compressed self-index of the document's text nodes. Most queries, however, contain some parts of querying the text of the document, plus(More)
This article is the first part of a two articles series about a calculus with higher-order polymorphic functions, recursive types with arrow and product type constructors and set-theoretic type connectives (union, intersection, and negation). In this first part we define and study the explicitly-typed version of the calculus in which type instantiation is(More)
Although retroviruses are relatively promiscuous in choice of integration sites, retrotransposons can display marked integration specificity. In yeast and slime mold, some retrotransposons are associated with tRNA genes (tDNAs). In the Saccharomyces cerevisiae genome, the long terminal repeat retrotransposon Ty3 is found at RNA polymerase III (Pol III)(More)
XML transformations are very sensitive to types: XML types describe the tags and attributes of XML elements as well as the number, kind, and order of their sub-elements. Therefore, operations, even simple ones, that modify these features may affect the types of documents. Operations on XML documents are performed by iterators that, to be useful, need to be(More)