Kim Mark Knudsen

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The efficacy and safety of zanolimumab in patients with refractory cutaneous T-cell lymphoma (CTCL) have been assessed in two phase 2, multicenter, prospective, open-label, uncontrolled clinical studies. Patients with treatment refractory CD4(+) CTCL (mycosis fungoides [MF], n = 38; Sézary syndrome [SS], n = 9) received 17 weekly infusions of zanolimumab(More)
IL-8 is a chemokine that has been implicated in a number of inflammatory diseases involving neutrophil activation. HuMab 10F8 is a novel fully human mAb against IL-8, which binds a discontinuous epitope on IL-8 overlapping the receptor binding site, and which effectively neutralizes IL-8-dependent human neutrophil activation and migration. We investigated(More)
IMPORTANCE An association between the metabolic syndrome (MetS) and chronic inflammatory diseases, such as psoriasis or rheumatoid arthritis, has been suggested.Hidradenitis suppurativa (HS), a more localized chronic inflammation of the skin, has been speculated to have a similar association. Hidradenitis suppurativa is a substantial burden for the(More)
The bioequivalence of recombinant human growth hormone (rhGH) for reconstitution, at either 24 IU or 8 mg, and three strengths of liquid formulation of rhGH (5, 10 or 15 mg per 1.5 ml, hGH) was tested in two randomized, single-blind, four-period, crossover studies in healthy subjects. The study drugs were administered by subcutaneous injection at a dose of(More)
The Cox regression model with a frailty factor allows for unobserved heterogeneity or for statistical dependence between the observed survival times. Estimation in this model is reviewed and we address the problem of obtaining variance estimates for regression coe cients, frailty parameter, and cumulative baseline hazards using the observed non-parametric(More)
1Multidisciplinary Cutaneous Lymphoma Program, Stanford Comprehensive Cancer Center, CA; 2M.D. Anderson Cancer Center, Houston, TX; 3Aarhus University Hospital, Denmark; 4Bispebjerg Hospital, Copenhagen, Denmark; 5Karolinska Hospital, Stockholm, Sweden; 6St Thomas’ Hospital, London, United Kingdom; 7Manchester University, Christie Hospital, United Kingdom;(More)
BACKGROUND Cryosurgery is the most commonly used method to treat actinic keratosis (AK). Cryosurgical methods are not standardized. OBJECTIVE To examine differences in the spray techniques used for liquid nitrogen cryosurgery when treating AKs of the head, and the effect of these variations in technique on rates of complete clearance of AKs. MATERIALS(More)
BACKGROUND Ingenol mebutate gel is a topical field treatment for actinic keratosis (AK). The treatment elicits application-site reactions in most patients. This analysis evaluated the relationship between the severity of reactions and the speed of their resolution. METHODS Patients in Phase III studies were treated for AKs on the face (n=218), scalp(More)
INTRODUCTION Cryosurgery is the most common treatment for actinic keratosis (AK) in the United States. Efficacy with cryosurgery is variable, and is a modality for treating individual, visible lesions while failing to treat subclinical lesions. METHODS FIELD Study 1 (NCT01541553) is a phase 3, multicenter, randomized, double-blind study that evaluated the(More)
The relationship between indices of the single-breath nitrogen test (SBNT) measured in 1974 and hospitalization in the 9 year period 1977–1986 was examined in a random population sample of 876 men aged 46–69 years. Men who could not perform acceptable SBNT tracings had an increased risk of hospitalization due to respiratory disease in general. When age and(More)