Kim Kristensen

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Elevated glucagon is associated with fasting hyperglycemia in type 2 diabetes. We assessed the effects of the glucagon receptor antagonist (2R)-N-[4-({4-(1-cyclohexen-1-yl)[(3,5-dichloroanilino)carbonyl]anilino}methyl)benzoyl]-2-hydroxy-b-alanine (NNC 25-0926) on hepatic glucose production (HPG) in vivo, using arteriovenous difference and tracer techniques(More)
In a retrospective questionnaire survey of 885 women who had given birth 3–5 months before, fewer of those who were still breast-feeding at 4 months (n=645) were using drugs than those who had stopped breast-feeding before 4 months (n=240), during the 2 week period preceding registration. The average number of doses (Defined Daily Doses/1000 women/day) was(More)
This study used 459 prospectively sampled cord blood samples to examine the association between maternally derived respiratory syncytial virus (RSV)-neutralizing antibodies and the RSV hospitalization season in Denmark. We found a clear temporal association and suggest that RSV-neutralizing antibody level plays a role in the RSV seasonal pattern.
Artesunate (AS) is used in combination with amodiaquine (AQ) as first-line treatment for uncomplicated malaria in many countries. We investigated the effect of concomitant AS administration on the pharmacokinetics of AQ and compared concentrations of desethylamodiaquine (DEAQ), the main metabolite of AQ, in plasma between patients with different variants of(More)
The house fly (Musca domestica L.) may transmit Campylobacter to broiler flocks. We assessed the retention time of house flies for Campylobacter jejuni at five temperatures and three doses. Flies were inoculated individually at their proboscis with 1.6 x 10(7) CFU (colony forming units) of C. jejuni and incubated at 15, 20, 25, 30, and 35 degrees C.(More)
It is currently debated whether the mechanism of action of therapeutic doses of recombinant factor VIIa (rFVIIa, Novo-Seven) relies on the tissue factor (TF)-independent activity of the enzyme. The present study was conducted to investigate the in vivo hemostatic effects of rFVIIa and 3 analogs thereof with superior intrinsic activity (FVIIaIIa,(More)
OBJECTIVES This study examined whether atopic disposition, wheezing, and atopic disorders increased the risk of hospitalizations because of respiratory syncytial virus in children between birth and 18 months of age. PATIENTS AND METHODS Relative risks for respiratory syncytial virus hospitalization were studied in a nested 1:5 case-control design using(More)
OBJECTIVE To evaluate the antibody response to a Haemophilus influenzae type b capsular polysaccharide (HibCP) tetanus toxoid (TT) conjugate vaccine (HibCP-TT) in preterm infants. SUBJECTS Thirty-five healthy preterm infants with gestational ages (GA) from 27 to 36 weeks and birth weights from 920 to 2550 g. Controls were 37 term infants. METHODS All(More)
BACKGROUND Respiratory syncytial virus (RSV) hospitalization is associated with wheeze. OBJECTIVE To examine the influence of maternally derived RSV neutralizing antibodies in cord blood on RSV hospitalization and recurrent wheeze in infancy. METHODS Among children from the Danish National Birth Cohort, we selected a subcohort of 459 randomly selected(More)
OBJECTIVES To estimate the incidence of bleeding leading to death or hospital admission in out-patients treated with oral anticoagulants. DESIGN Population-based historical cohort study 1 January 1992 to 31 September 1994. SETTING The County of North Jutland, Denmark (488,000 inhabitants). SUBJECTS Six hundred and eighty-two consecutive patients(More)