Kim Ellen Schmidt

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A severe complication of Plasmodium infection is cerebral malaria, a condition mainly attributed to overwhelming inflammatory immune reactions of the host. Murine models differing in susceptibility to experimental cerebral malaria (ECM) allow detailed studies of the host response. We show that ECM- resistant BALB/c mice were driven into interferon gamma-(More)
Cerebral malaria is a severe and often fatal complication of Plasmodium falciparum infection. It is characterized by parasite sequestration, a breakdown of the blood-brain barrier, and a strong inflammation in the brain. We investigated the role of the cannabinoid receptor 2 (CB2), an important modulator of neuroinflammatory responses, in experimental(More)
Vector-transmitted parasitic infections are a global health problem. Diseases such as malaria are a major health threat and economic burden for developing countries. In Sub-Saharan Africa malaria causing Plasmodium parasites may evoke life threatening complications, which mainly affect children under the age of five years. Pathogenesis of cerebral malaria(More)
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