Kikuo Nomoto

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We have previously reported that T cells bearing T cell receptors (TCRs) of 3`//$ type appear at a relatively early stage of primary infection with Listeria monocytogenes in mice. To characterize the early-appearing 3`//$ T cells during listeriosis, we analyzed the specificity and cytokine production of the 3`//$ T cells in the peritoneal cavity in mice(More)
Transplantation of bone marrow cells of lpr/lpr mice into irradiated normal mice fails to develop massive lymphadenopathy or autoimmunity but causes severe graft-vs.-host-like syndrome. To elucidate an abnormality of lpr/lpr bone marrow-derived T cells, we transplanted bone marrow cells of Mlsb lpr/lpr mice into H-2-compatible Mlsa non-lpr mice. Although(More)
Most T cells develop through the thymus, where they undergo positive and negative selection. Some peripheral T cells are known to develop in the absence of thymus, but there is insufficient information about their selection. To analyze the selection of extrathymically developed T cells, we reconstituted thymectomized male or female recipient mice with bone(More)
When C3H (H-2k, Mls-1b) mice were primed intravenously with 10(8) viable spleen cells from AKR (H-2k, Mls-1a) and treated intraperitoneally with 200 mg/kg of cyclophosphamide (CP) 2 d later, not only a long-lasting skin allograft tolerance but also a tolerance in mixed lymphocyte reaction to Mls-1a-encoded antigens was established. The cellular mechanisms(More)
In this study, we investigated the cytolytic activity of peripheral blood T-cells ll'lil i obtained from nine patients with primary lung cancer treated by surgical adjuvant adoptive immunothcrapy (AIT) with lym-phokine-activated killer cells and low-dose recombinant interleukin 2 at the time of rebound lymphocytosis (24-48 h after AIT). In eight of nine(More)
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