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To document synaptic interactions between neurons in the precentral cortex of macaque monkeys, we recorded in vivo the intracellular (IC) membrane potentials of cortical neurons simultaneously with extracellular (EC) action potentials of neighboring cells. The synaptic potentials correlated with EC spikes were obtained by spike-triggered averages (STA) of(More)
While we have a fair understanding of how and where forelimb-hand manipulative movements are controlled by the neocortex, due to functional imaging studies, we know little about the control of bipedal movements such as walking because of technical difficulties. We succeeded in visualizing cortical activation patterns of human gait by measuring relative(More)
1. We examined single-neuronal activity in the temporal pole of monkeys, including the anterior ventromedial temporal (VMT) cortex (the temporopolar cortex, area 36, area 35, and the entorhinal cortex) and the anterior inferotemporal (IT) cortex, during a visual recognition memory task. In the task, a trial began when the monkey pressed a lever. After a(More)
The corticocortical connections between the arcuate area (Walker's areas 8A and 45 or Brodmann's area 8) and the premotor and supplementary motor areas (Vogts' area 6) in the brain of the macaque monkey were studied microscopically with wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP), which was injected into Brodmann's area 8 primarily to(More)
1. Using iontophoretic techniques, we investigated the influence of dopamine (DA) antagonists [haloperidol (HAL), a non-selective DA antagonist; sulpiride (SUL), a selective antagonist for D2 receptors; and fluphenazine (FLU), a potent antagonist for D1 receptors] on neuronal activity related to a delayed response (DR) task in the monkey prefrontal cortex(More)
In four macaque monkeys horseradish peroxidase (HRP) was injected into physiologically defined hand-arm motor area. Ipsilaterally, HRP labeled neurons were found in both upper and lower limbs of the posterior bank of the arcuate sulcus and in an area surrounding the arcuate spur. Contralaterally, labeled neurons were found in the same areas, though less(More)
1. Using iontophoretic techniques, we investigated the effects of dopamine (DA) and noradrenaline (NA) on neuronal activity related to a delayed response (DR) task in the prefrontal cortex (PFC) of the Japanese macaque monkeys. The DR task was initiated by rotation of a handle to a central zone and consisted of seven distinct time periods: an initial(More)
Identification of familiar people is essential in our social life. We can identify familiar people by hearing their voices as well as by viewing their faces. By measuring regional cerebral blood flow (rCBF) by positron emission tomography (PET), we identified neural substrates for the recognition of familiar voices. The brain activity during discrimination(More)
In this article, we consider both the ventral temporopolar cortex and the perirhinal cortex (areas 35 and 36) as the anterior ventromedial temporal (aVMT) cortex, and discuss its role based on recent data in monkeys and human subjects. In monkeys, the aVMT cortex receives its primary input from area TE, and only minor input from other cortical areas.(More)
The effects of clonidine (a selective agonist for alpha-2 receptor) and B-HT920 (an agonist for both alpha-2 and D2 receptors) were examined iontophoretically on neurons in the prefrontal cortex of three monkeys performing a visual discrimination task with GO and NO-GO responses. A total of 212 task-related neurons were sampled, of which 120 neurons were(More)