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MicroRNAs (miRNAs) have recently come to be viewed as critical players that modulate a number of cellular features in various biological systems including the mature CNS by exerting regulatory control over the stability and translation of mRNAs. Despite considerable evidence for the regulatory functions of miRNAs, the identities of the miRNA species that(More)
In this talk I will overview a survey paper developed from the DOE-­‐sponsored Institute for Computing in Science Workshop on " Multiphysics Simulations: Challenges and Opportunities. " In this paper, we considered multiphysics applications from algorithmic and architectural perspectives where " architectural " included both software and hardware(More)
In this study, we explored whether phloroglucinol (1,3,5-trihydroxybenzene) exerts protective effects against oxidative stress–induced cytotoxicity in SH-SY5Y cells, a neuroblastoma cell line. The central nervous system is especially vulnerable to oxidative stress because the brain consumes large amounts of energy to perform its complicated functions,(More)
A time-spectral and adjoint-based optimization procedure that is particularly efficient for the analysis and shape design of helicopter rotors is developed. The time-spectral method is a fast and accurate algorithm to simulate periodic, unsteady flows by transforming them to a steady-state analysis using a Fourier spectral derivative temporal operator. An(More)
Neuritin, also known as CPG15, is a neurotrophic factor that was initially discovered in a screen to identify genes involved in activity-dependent synaptic plasticity. Neuritin plays multiple roles in the process of neural development and synaptic plasticity, although its binding receptor(s) and downstream signaling effectors remain unclear. In this study,(More)
We report the effects of various substrates and substrate thicknesses on electrospun poly(vinylidene fluoride) (PVDF)-nanofiber-based energy harvesters. The electrospun PVDF nanofibers showed an average diameter of 84.6 ± 23.5 nm. A high relative β-phase fraction (85.2%) was achieved by applying high voltage during electrospinning. The prepared PVDF(More)
MicroRNAs have emerged as key factors in development, neurogenesis and synaptic functions in the central nervous system. In the present study, we investigated a pathophysiological significance of microRNA-188-5p (miR-188-5p) in Alzheimer's disease (AD). We found that oligomeric Aβ1-42 treatment diminished miR-188-5p expression in primary hippocampal neuron(More)
Microglial cells, the resident immune cells of the spinal cord, become activated in response to peripheral nerve injury. Microglia activation contributes to the development of neuropathic pain. Here we employed microarray analysis of individually collected pools of 10 spinal microglia cells to identify changes of levels and cell-to-cell expression variance(More)
Exposure to valproic acid (VPA) during pregnancy has been linked with increased incidence of autism, and has repeatedly been demonstrated as a useful autism mouse model. We examined the early behavioral and anatomical changes as well as molecular changes in mice prenatally exposed to VPA (VPA mice). In this study, we first showed that VPA mice showed(More)
A hybrid architecture consisting of an inverted organic photovoltaic device and a randomly-oriented electrospun PVDF piezoelectric device was fabricated as a highly-efficient energy generator. It uses the inverted photovoltaic device with coupled electrospun PVDF nanofibers as tandem structure to convert solar and mechanical vibrations energy to electricity(More)