Kieran A. Brune

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BACKGROUND Young-onset cancer is a hallmark of many familial cancer syndromes, yet the implications of young-onset disease in predicting risk of pancreatic cancer among familial pancreatic cancer (FPC) kindred members remain unclear. METHODS To understand the relationship between age at onset of pancreatic cancer and risk of pancreatic cancer in kindred(More)
PURPOSE To assess patient views regarding the value of genetic counselling for familial pancreas cancer in the absence of predictive genetic testing. PATIENTS AND METHODS At-risk adults with three or more relatives with pancreas cancer received genetic counselling prior to research screening via endoscopic ultrasound. Questionnaires were mailed after the(More)
Several clinical studies show that individuals with HIV are at an increased risk for worsened lung function and for the development of COPD, although the mechanism underlying this increased susceptibility is poorly understood. The airway epithelium, situated at the interface between the external environment and the lung parenchyma, acts as a physical and(More)
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