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OBJECTIVE To describe probabilities and characteristics of disease flares in children with juvenile idiopathic arthritis (JIA) and to identify clinical features associated with an increased risk of flare. METHODS We studied children in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) prospective inception cohort. A flare(More)
INTRODUCTION The aim of this study was to assess cancer incidence in childhood-onset systemic lupus erythematosus (SLE). METHODS We ascertained cancers within SLE registries at 10 pediatric centers. Subjects were linked to cancer registries for the observational interval, spanning 1974 to 2009. The ratio of observed to expected cancers represents the(More)
OBJECTIVE To determine cancer incidence in a large clinical juvenile-onset arthritis population. METHODS We combined data from 6 existing North American juvenile-onset arthritis cohorts. Patients with juvenile-onset arthritis were linked to regional cancer registries to detect incident cancers after cohort entry, defined as first date seen in the(More)
Purpose To examine the remission rates and functional outcomes in an inception cohort of patients with juvenile idiopathic arthritis (JIA). Methods The Research in Arthritis in Canadian Children, emphasizing Outcomes (ReACCh-Out) cohort is a 16-centre inception cohort of patients with JIA enrolled within 1 year of diagnosis. All patients who completed 5(More)
Purpose The ability to predict which children with Juvenile idio-pathic Arthritis (JIA) are likely to have worse outcomes would allow a more targeted aggressive approach to initial therapy. We used data from the Research on Arthritis in Canadian Children Emphasizing Outcomes (ReACCh Out), a 16-centre prospective inception cohort of children with newly(More)
Purpose Compromised bone health is recognized as an important source of morbidity among children with glucocorticoid (GC)-treated rheumatic diseases (RD). The aims of this study were to determine the frequency and characteristics of incident vertebral fractures (VF) 12 months after GC initiation in a prospectively-followed cohort of children with RD, and to(More)
Purpose To describe the longitudinal active joint count (AJC) trajectories in juvenile idiopathic arthritis (JIA) and to examine the association of baseline characteristics with these trajectories. Methods A retrospective cohort study at two Canadian centres was performed. The longitudinal trajectories of AJC were described using latent growth curve(More)
Purpose Corticosteroids (CS) are commonly used for the treatment of children with rheumatic diseases (RD) at presentation or relapse; the dose is reduced or discontinued with disease improvement. The aim of this study was to examine the dose-related effect of CS on the timing of peak body mass index (BMI) in children with RD and the degree of restitution to(More)
Chronic childhood arthritis affecting more than four joints during the first 6 months of disease is defined as polyarthritis. 1,2 In the classification of the International League of Associations for Rheumatology (ILAR), 2 poly-arthritis is further categorized as rheumatoid factor (RF) negative if tests for RF are negative, and RF positive if RF is detected(More)
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