Kichun Sky Lee

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Progression of Parkinson's disease (PD) is highly variable, indicating that differences between slow and rapid progression forms could provide valuable information for improved early detection and management. Unfortunately, this represents a complex problem due to the heterogeneous nature of humans in regards to demographic characteristics, genetics, diet,(More)
Breast cancer is the second leading cause of death in women in the United States. Breast Magnetic Resonance Imaging (BMRI) is an emerging tool in breast cancer diagnostics and research, and it is becoming routine in clinical practice. Recently, the American Cancer Society (ACS) recommended that women at very high risk of developing breast cancer have annual(More)
High-performance metabolic profiling (HPMP) by Fourier-transform mass spectrometry coupled to liquid chromatography gives relative quantification of thousands of chemicals in biologic samples but has had little development for use in toxicology research. In principle, the approach could be useful to detect complex metabolic response patterns to toxicologic(More)
PURPOSE To determine if plasma metabolic profiles can detect differences between patients with neovascular age-related macular degeneration (NVAMD) and similarly-aged controls. METHODS Metabolomic analysis using liquid chromatography with Fourier-transform mass spectrometry (LC-FTMS) was performed on plasma samples from 26 NVAMD patients and 19 controls.(More)
Breath analysis has received attention as a noninvasive diagnostic tool with increasing research into its potential usefulness. We are investigating the utility of the analysis of breath volatile organic compounds (VOCs) as an effective modality for breast cancer (BC) detection and monitoring by collecting breath samples with a simple portable device to(More)
Many environmental time-evolving spatial phenomena are characterized by a large number of energetic modes, the occurrence of irregularities, and self-organization over a wide range of space or time scales. Precipitation is a classical example characterized by both strong intermittency and multiscale dynamics, and these features generate persistence,(More)
The concept of multifractality is currently used to describe self-similar and complex scaling properties observed in numerous biological signals. Fractals are geometric objects or dynamic variations which exhibit some degree of similarity (irregularity) to the original object in a wide range of scales. This approach determines irregularity of biologic(More)
The content of sulfur amino acid (SAA) in a meal affects postprandial plasma cysteine concentrations and the redox potential of cysteine/cystine. Because such changes can affect enzyme, transporter, and receptor activities, meal content of SAA could have unrecognized effects on metabolism during the postprandial period. This pilot study used proton NMR(More)
OBJECTIVE Improved means to monitor and guide interventions could be useful in the intensive care unit. Metabolomic analysis with bioinformatics is used to understand mechanisms and identify biomarkers of disease development and progression. This pilot study evaluated plasma proton nuclear magnetic resonance spectroscopy as a means to monitor metabolism(More)
The aim of this paper is to present results from a comparative investigation into the diagnostic performance of several wavelet-based estimators of scaling, some from published literature and some newly proposed. These estimators are evaluated based on their ability to classify digitized mammogram images from a clinical database, for which the true disease(More)