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Endoplasmic reticulum (ER) stress is closely connected to autophagy. When cells are exposed to ER stress, cells exhibit enhanced protein degradation and form autophagosomes. In this study, we demonstrate that the chemical chaperone, 4-phenylbutyric acid (4-PBA), regulates ER stressinduced cell death and autophagy in human gingival fibroblasts. We found that(More)
We have previously shown that Candida albicans mannan extract encapsulated in liposomes [Lipo-mann] or conjugated to a protein (bovine serum albumin) [Conju-mann] induces the production of antibody in BALB/c mice with normal complement system that protect against disseminated candidiasis. In this present study, we determined the protective abilities of two(More)
The role of an antibody against candidiasis is controversial. However, a certain Candida albicans surface epitope produces a protective antibody. Yet, its isolation is difficult. In this study, we investigated if ginsenoside Rd from Panax ginseng has an immunoadjuvant ability to induce surface mannan extract (CASM) to produce a protective antibody. Mice(More)
OBJECTIVES To construct a database of published clinical drug trials suitable for use 1) as a research tool in accessing clinical trial information and 2) in evidence-based decision-making by regulatory professionals, clinical research investigators, and medical practitioners. MATERIALS Comprehensive information obtained from a search of design elements(More)
N-Nitrosodialkylamines are considered a potential health hazard for humans. Among various N-nitrosodialkylamines compound, N-nitrosodimethylamine (NDMA), was applied to lung cells, MLG. In order to examine the effect of NDMA in lung cells, cell death was first examined. NDMA induced cell death in a dose-dependent manner. Mitogen activated protein kinase(More)
Puerarin [4H-1-benzopyran-4-one,8-b-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)] is the major bioactive constituent in galgeun, which is the dried root of Puerariae Radix. For more than 2,000 years, galgeun has been widely used as an herbal medicine for its potential benefits on the treatment of common cold, diabetes and cardiovascular diseases in(More)
Purpose To explore the need for pharmaceutical care services, key features of desirable pharmacy services, and perceived barriers for advancing the services in hospital environments with doctors and nurses who are key co-workers of the interdisciplinary team care services.Methods Semi-structured, in-depth interviews with eighteen doctors and fifteen nurses(More)
The adjuvant effect of icariin from Epimedium koreanum on the immune responses to bovine serum albumin (BSA) in mice was examined. Mice were immunized on days 1 and 22 intraperitoneally (i.p.) with one of the following: an emulsion form of BSA mixed with Incomplete Freund's Adjuvant (BSA/IFA) or with Complete Freund's Adjuvant (BSA/CFA) or BSA plus icariin(More)
CASE Acyclovir is a widely administered medication for viral infection but is well known for its nephrotoxicity. To date, few studies regarding the safety of alternative antiviral agents have been reported. This study reports the case of a patient with renal dysfunction who suffers from acute herpes zoster (shingles) on her back. While renal function(More)
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