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Carbon Monoxide Induces Heme Oxygenase-1 via Activation of Protein Kinase R–Like Endoplasmic Reticulum Kinase and Inhibits Endothelial Cell Apoptosis Triggered by Endoplasmic Reticulum Stress
TLDR
These findings suggest that CO renders endothelial cells resistant to ER stress not only by downregulating C/EBP homologous protein expression via p38 mitogen-activated protein kinase activation but also by upregulating Nrf2-dependent HO-1 expression via PERK activation. Expand
Curcumin induces pro-apoptotic endoplasmic reticulum stress in human leukemia HL-60 cells.
TLDR
The present study shows that curcumin-induced apoptosis is associated with its ability to cause ER stress. Expand
Pretreatment of Acetylsalicylic Acid Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Down-regulating BCL-2 Gene Expression*
TLDR
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be selective in the induction of apoptosis in cancer cells with minimal toxicity to normal tissues and studies suggested that ASA-promoted TRAIL cytotoxicity is mediated through down-regulating BCL-2 and by decreasing mitochondrial membrane potential. Expand
Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose.
TLDR
It is suggested that GLO-1 plays a role in high glucose-mediated signaling by reducing MG accumulation and oxidative stress in diabetes mellitus. Expand
Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages.
TLDR
Evidence is provided to support the important role of HO-1 in inhibition of NO production and iNOS expression byCurcumin even at low concentrations, and treatment with HO inhibitor abolished the inhibitory effect of curcumin on LPS-induced NF-kappaB activation. Expand
In-vitro anticancer activity of green synthesized silver nanoparticles on MCF-7 human breast cancer cells.
TLDR
Silver NPs were found to be significantly toxic to MCF-7 cells via the induction of apoptosis whereas sparing normal immune system cells, and characterized using UV-Vis spectroscopy, FTIR, SEM-ED, TEM and SAED. Expand
Magnolol Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Inhibiting Ras-Dependent Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways
TLDR
It is demonstrated that magnolol is an inhibitor of angiogenesis and suggested that this compound could be a potential candidate in the treatment ofAngiogenesis-related diseases. Expand
Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression.
TLDR
It is demonstrated that puerarin-induced expression of HO-1 is mediated by the PKC delta-Nrf-2-HO-1 pathway and inhibits N-carboxymethyllysine (CML)-induced inflammation in mouse mesangial cells. Expand
Timosaponin AIII inhibits melanoma cell migration by suppressing COX‐2 and in vivo tumor metastasis
TLDR
Results indicate that timosaponin AIII has the capacity to inhibit melanoma cell migration, an essential step in the process of metastasis, by inhibiting expression of COX‐2, NF‐κB, P GE2, and PGE2 receptors. Expand
Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway
TLDR
The present studies suggest that amiloride enhances TRAIL-induced cytotoxicity by inhibiting phosphorylation of the PI3K-Akt pathway-associated kinases and phosphatases. Expand
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