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Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.
Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete,
Tirucallane triterpenoids from Cornus walteri.
TLDR
Twelve new tirucallane triterpenoids were isolated from a MeOH extract of stems and stem bark of Cornus walteri, and possessing a tetrahydrofuran ring in the side chain exhibited significant cytotoxic activity against the A549, SK-OV-3,SK-MEL-2, and XF498 cell lines.
Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization.
TLDR
It was determined that sulforaphene is a potent inhibitor of microtubule polymerization while generating reactive oxygen species via the depletion of glutathione and may contribute to the anti-tumor effects of cruciferous vegetables that contain sul foraphene and other isothiocyanates.
Butein is a novel anti-adipogenic compound[S]
TLDR
It is shown that butein, a novel anti-adipogenic compound from RVS, inhibits adipocyte differentiation through the TGF-β pathway followed by STAT3 and peroxisome proliferator-activated receptor γ signaling, further implicating potential roles ofbutein in T GF-β- and STAT3-dysregulated diseases.
Iridoid glycosides from Barleria lupulina.
TLDR
Phytochemical investigation of an extract of the aerial part of Barleria lupulina resulted in the identification of four new iridoid glycosides (1-4), together with 14 known analogues (5-18), the first report of iridoids with a formate group.
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